Pannexin 1 in the Regulation of Vascular Tone

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2012 Jul 31

PMID 22841835

Citations 25

Authors

Marie Billaud

Joanna K Sandilos

Brant E Isakson

Affiliations

Soon will be listed here.

Abstract

Pannexins are a recently discovered protein family with the isoform Panx1 ubiquitously expressed and therefore extensively studied. Panx1 proteins form membrane channels known to release purines such as ATP. Because ATP and, more generally, purinergic signaling plays an important role in the vasculature, it became evident that Panx1 could have a key role in vascular functions. This article reviews recent findings on the pivotal role of Panx1 in smooth muscle cells in the contraction of arteries as well as recent insights into Panx1 channel regulation.

Citing Articles

Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons.

Lucero C, Prieto-Villalobos J, Marambio-Ruiz L, Balmazabal J, Alvear T, Vega M Int J Mol Sci. 2022; 23(24).

PMID: 36555574 PMC: 9785367. DOI: 10.3390/ijms232415936.

Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion.

Cibelli A, Scemes E, Spray D Cells. 2022; 11(20).

PMID: 36291086 PMC: 9600160. DOI: 10.3390/cells11203219.

Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function.

Burboa P, Puebla M, Gaete P, Duran W, Lillo M Int J Mol Sci. 2022; 23(13).

PMID: 35806312 PMC: 9266979. DOI: 10.3390/ijms23137303.

A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in Knockout Mice.

Meter D, Racetin A, Vukojevic K, Balog M, Ivic V, Zjalic M Int J Mol Sci. 2022; 23(11).

PMID: 35682927 PMC: 9181035. DOI: 10.3390/ijms23116237.

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation.

Filiberto A, Spinosa M, Elder C, Su G, Leroy V, Ladd Z Nat Commun. 2022; 13(1):1521.

PMID: 35315432 PMC: 8938517. DOI: 10.1038/s41467-022-29233-4.

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