Immunological Complications of Obesity

Overview

Journal Nat Immunol

Date 2012 Jul 21

PMID 22814340

Citations 242

Authors

Thirumala-Devi Kanneganti

Vishwa Deep Dixit

Affiliations

Soon will be listed here.

Abstract

Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved understanding of the immunological processes that regulate obesity may yield new treatments for obesity-associated disorders.

Citing Articles

The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation.

Yu W, Sun S, Fu Q Front Immunol. 2025; 16:1519925.

PMID: 39991152 PMC: 11842938. DOI: 10.3389/fimmu.2025.1519925.

Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations.

Li Y, Guo X, Ge J, Li Q, Chen X, Zhu Y Lipids Health Dis. 2025; 24(1):50.

PMID: 39953587 PMC: 11829553. DOI: 10.1186/s12944-025-02473-1.

Inflammatory Th17 cells are correlated with insulin resistance and erythrocyte parameters in overweight and obese children.

Artemniak-Wojtowicz D, Ruminska M, Stelmaszczyk-Emmel A, Paluchowska M, Pyrzak B, Kucharska A Front Endocrinol (Lausanne). 2024; 15:1456203.

PMID: 39610842 PMC: 11602275. DOI: 10.3389/fendo.2024.1456203.

Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery.

De Luca S, Gunatilaka A, Coward-Smith M, Gomez H, Kim R, Stenekes A ACS Pharmacol Transl Sci. 2024; 7(11):3385-3393.

PMID: 39539266 PMC: 11555503. DOI: 10.1021/acsptsci.4c00484.

Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 2-Secondary Immunodeficiencies.

Napiorkowska-Baran K, Doligalska A, Drozd M, Czarnowska M, Laszczych D, Dolina M Healthcare (Basel). 2024; 12(19).

PMID: 39408157 PMC: 11477378. DOI: 10.3390/healthcare12191977.

References

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

Spiegelman B, Flier J . Obesity and the regulation of energy balance. Cell. 2001; 104(4):531-43. DOI: 10.1016/s0092-8674(01)00240-9. View

Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C . Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005; 54(8):2277-86. DOI: 10.2337/diabetes.54.8.2277. View

Duewell P, Kono H, Rayner K, Sirois C, Vladimer G, Bauernfeind F . NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010; 464(7293):1357-61. PMC: 2946640. DOI: 10.1038/nature08938. View

Wu D, Molofsky A, Liang H, Ricardo-Gonzalez R, Jouihan H, Bando J . Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011; 332(6026):243-7. PMC: 3144160. DOI: 10.1126/science.1201475. View

Yang H, Youm Y, Vandanmagsar B, Rood J, Kumar K, Butler A . Obesity accelerates thymic aging. Blood. 2009; 114(18):3803-12. PMC: 2773495. DOI: 10.1182/blood-2009-03-213595. View

Winer D, Winer S, Shen L, Wadia P, Yantha J, Paltser G . B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011; 17(5):610-7. PMC: 3270885. DOI: 10.1038/nm.2353. View

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal W, Strowig T . Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012; 482(7384):179-85. PMC: 3276682. DOI: 10.1038/nature10809. View

Masters S, Dunne A, Subramanian S, Hull R, Tannahill G, Sharp F . Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol. 2010; 11(10):897-904. PMC: 3103663. DOI: 10.1038/ni.1935. View

10.

Stienstra R, Tack C, Kanneganti T, Joosten L, Netea M . The inflammasome puts obesity in the danger zone. Cell Metab. 2012; 15(1):10-8. DOI: 10.1016/j.cmet.2011.10.011. View

11.

Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A . Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009; 15(8):930-9. PMC: 3115752. DOI: 10.1038/nm.2002. View

12.

Fuji S, Kim S, Yoshimura K, Akiyama H, Okamoto S, Sao H . Possible association between obesity and posttransplantation complications including infectious diseases and acute graft-versus-host disease. Biol Blood Marrow Transplant. 2009; 15(1):73-82. DOI: 10.1016/j.bbmt.2008.10.029. View

13.

Lukens J, Dixit V, Kanneganti T . Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. Discov Med. 2011; 12(62):65-74. PMC: 4266394. View

14.

Youm Y, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit V . Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology. 2011; 152(11):4039-45. PMC: 3199005. DOI: 10.1210/en.2011-1326. View

15.

Westermark G, Westermark P, Berne C, Korsgren O . Widespread amyloid deposition in transplanted human pancreatic islets. N Engl J Med. 2008; 359(9):977-9. DOI: 10.1056/NEJMc0802893. View

16.

Furet J, Kong L, Tap J, Poitou C, Basdevant A, Bouillot J . Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010; 59(12):3049-57. PMC: 2992765. DOI: 10.2337/db10-0253. View

17.

Bouhlel M, Derudas B, Rigamonti E, Dievart R, Brozek J, Haulon S . PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 2007; 6(2):137-43. DOI: 10.1016/j.cmet.2007.06.010. View

18.

Lumeng C, Bodzin J, Saltiel A . Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117(1):175-84. PMC: 1716210. DOI: 10.1172/JCI29881. View

19.

Karlsson E, Sheridan P, Beck M . Diet-induced obesity impairs the T cell memory response to influenza virus infection. J Immunol. 2010; 184(6):3127-33. DOI: 10.4049/jimmunol.0903220. View

20.

Gregor M, Hotamisligil G . Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011; 29:415-45. DOI: 10.1146/annurev-immunol-031210-101322. View