Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

Overview

Journal Int J Biomed Imaging

Publisher Wiley

Specialty Radiology

Date 2012 Jul 14

PMID 22792084

Citations 110

Authors

Roberto Reif

Jia Qin

Lin An

Zhongwei Zhi

Suzan Dziennis

Ruikang Wang

Affiliations

Soon will be listed here.

Abstract

The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained with a spectral domain optical coherence tomography system. A technique for determining three measureable parameters (the fractal dimension, the vessel length fraction, and the vessel area density) is proposed and validated. Finally, the repeatability for acquiring OMAG images is determined, and a new method for analyzing small areas from these images is proposed.

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