IncA/C Plasmids: An Emerging Threat to Human and Animal Health?

Overview

Journal Mob Genet Elements

Date 2012 Jul 4

PMID 22754754

Citations 36

Authors

Timothy J Johnson

Kevin S Lang

Affiliations

Soon will be listed here.

Abstract

Incompatibility group IncA/C plasmids are large, low copy, theta-replicating plasmids that have been described in the literature for over 40 years. However, they have only recently been intensively studied on the genomic level because of their associations with the emergence of multidrug resistance in enteric pathogens of humans and animals. These plasmids are unique among other enterobacterial plasmids in many aspects, including their modular structure and gene content. While the IncA/C plasmid genome structure has now been well defined, many questions remain pertaining to their basic biological mechanisms of dissemination and regulation. Here, we discuss the history of IncA/C plasmids in light of our recent understanding of their population distribution, genomics, and effects on host bacteria.

Citing Articles

The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.

Fang L, Chen R, Li C, Sun J, Liu R, Shen Y Front Cell Infect Microbiol. 2024; 14:1472876.

PMID: 39660283 PMC: 11628540. DOI: 10.3389/fcimb.2024.1472876.

IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in .

Allain M, Morel-Journel T, Condamine B, Gibeaux B, Gachet B, Gschwind R Antimicrob Agents Chemother. 2024; 68(10):e0055424.

PMID: 39194203 PMC: 11459957. DOI: 10.1128/aac.00554-24.

Identification of IncA Plasmid, Harboring Gene, in Goldcoast ST358 and ST62 Isolated in a Hospitalized Patient.

Piccirilli A, Di Marcantonio S, Costantino V, Simonetti O, Busetti M, Luzzati R Antibiotics (Basel). 2023; 12(12).

PMID: 38136693 PMC: 10741216. DOI: 10.3390/antibiotics12121659.

Engineering conjugative CRISPR-Cas9 systems for the targeted control of enteric pathogens and antibiotic resistance.

Sheng H, Wu S, Xue Y, Zhao W, Caplan A, Hovde C PLoS One. 2023; 18(9):e0291520.

PMID: 37699034 PMC: 10497133. DOI: 10.1371/journal.pone.0291520.

The Dynamics of the Antimicrobial Resistance Mobilome of and Related Enteric Bacteria.

Algarni S, Ricke S, Foley S, Han J Front Microbiol. 2022; 13:859854.

PMID: 35432284 PMC: 9008345. DOI: 10.3389/fmicb.2022.859854.

References

Diarrassouba F, Diarra M, Bach S, Delaquis P, Pritchard J, Topp E . Antibiotic resistance and virulence genes in commensal Escherichia coli and Salmonella isolates from commercial broiler chicken farms. J Food Prot. 2007; 70(6):1316-27. DOI: 10.4315/0362-028x-70.6.1316. View

Wantanabe T, Aoki T, Ogata Y, Egusa S . Anbtibiotics and drug resistance in animals. R factors related to fish culturing. Ann N Y Acad Sci. 1971; 182:383-410. DOI: 10.1111/j.1749-6632.1971.tb30674.x. View

Welch T, Fricke W, McDermott P, White D, Rosso M, Rasko D . Multiple antimicrobial resistance in plague: an emerging public health risk. PLoS One. 2007; 2(3):e309. PMC: 1819562. DOI: 10.1371/journal.pone.0000309. View

Arpin C, Thabet L, Yassine H, Messadi A, Boukadida J, Dubois V . Evolution of an incompatibility group IncA/C plasmid harboring blaCMY-16 and qnrA6 genes and its transfer through three clones of Providencia stuartii during a two-year outbreak in a Tunisian burn unit. Antimicrob Agents Chemother. 2011; 56(3):1342-9. PMC: 3294913. DOI: 10.1128/AAC.05267-11. View

Zaidi M, Leon V, Canche C, Perez C, Zhao S, Hubert S . Rapid and widespread dissemination of multidrug-resistant blaCMY-2 Salmonella Typhimurium in Mexico. J Antimicrob Chemother. 2007; 60(2):398-401. DOI: 10.1093/jac/dkm168. View

Suzuki H, Yano H, Brown C, Top E . Predicting plasmid promiscuity based on genomic signature. J Bacteriol. 2010; 192(22):6045-55. PMC: 2976448. DOI: 10.1128/JB.00277-10. View

Douard G, Praud K, Cloeckaert A, Doublet B . The Salmonella genomic island 1 is specifically mobilized in trans by the IncA/C multidrug resistance plasmid family. PLoS One. 2010; 5(12):e15302. PMC: 3004903. DOI: 10.1371/journal.pone.0015302. View

Dillon S, Cameron A, Hokamp K, Lucchini S, Hinton J, Dorman C . Genome-wide analysis of the H-NS and Sfh regulatory networks in Salmonella Typhimurium identifies a plasmid-encoded transcription silencing mechanism. Mol Microbiol. 2010; 76(5):1250-65. DOI: 10.1111/j.1365-2958.2010.07173.x. View

Ding H, Yang Y, Lu Q, Wang Y, Chen Y, Deng L . The prevalence of plasmid-mediated AmpC beta-lactamases among clinical isolates of Escherichia coli and Klebsiella pneumoniae from five children's hospitals in China. Eur J Clin Microbiol Infect Dis. 2008; 27(10):915-21. DOI: 10.1007/s10096-008-0532-4. View

10.

Fricke W, Welch T, McDermott P, Mammel M, Leclerc J, White D . Comparative genomics of the IncA/C multidrug resistance plasmid family. J Bacteriol. 2009; 191(15):4750-7. PMC: 2715731. DOI: 10.1128/JB.00189-09. View

11.

Allen K, Poppe C . Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by beta-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Can J Vet Res. 2002; 66(3):137-44. PMC: 226996. View

12.

Daniels J, Call D, Besser T . Molecular epidemiology of blaCMY-2 plasmids carried by Salmonella enterica and Escherichia coli isolates from cattle in the Pacific Northwest. Appl Environ Microbiol. 2007; 73(24):8005-11. PMC: 2168131. DOI: 10.1128/AEM.01325-07. View

13.

Yun C, Suzuki C, Naito K, Takeda T, Takahashi Y, Sai F . Pmr, a histone-like protein H1 (H-NS) family protein encoded by the IncP-7 plasmid pCAR1, is a key global regulator that alters host function. J Bacteriol. 2010; 192(18):4720-31. PMC: 2937398. DOI: 10.1128/JB.00591-10. View

14.

Giles W, Benson A, Olson M, Hutkins R, Whichard J, Winokur P . DNA sequence analysis of regions surrounding blaCMY-2 from multiple Salmonella plasmid backbones. Antimicrob Agents Chemother. 2004; 48(8):2845-52. PMC: 478531. DOI: 10.1128/AAC.48.8.2845-2852.2004. View

15.

Poole T, Edrington T, Brichta-Harhay D, Carattoli A, Anderson R, Nisbet D . Conjugative transferability of the A/C plasmids from Salmonella enterica isolates that possess or lack bla(CMY) in the A/C plasmid backbone. Foodborne Pathog Dis. 2009; 6(10):1185-94. DOI: 10.1089/fpd.2009.0316. View

16.

Kang M, Besser T, Call D . Variability in the region downstream of the blaCMY-2 beta-lactamase gene in Escherichia coli and Salmonella enterica plasmids. Antimicrob Agents Chemother. 2006; 50(4):1590-3. PMC: 1426964. DOI: 10.1128/AAC.50.4.1590-1593.2006. View

17.

Watanabe T . Infective heredity of multiple drug resistance in bacteria. Bacteriol Rev. 1963; 27:87-115. PMC: 441171. DOI: 10.1128/br.27.1.87-115.1963. View

18.

Bauernfeind A, Stemplinger I, Jungwirth R, Giamarellou H . Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance. Antimicrob Agents Chemother. 1996; 40(1):221-4. PMC: 163087. DOI: 10.1128/AAC.40.1.221. View

19.

Zhang Y, Peng J, Wang Q, Pei Z, Zhang W, Niu Z . Appearance of blaCMY-2)gene-positive Salmonella isolates of pig origin in China. Int J Antimicrob Agents. 2008; 31(3):292-3. DOI: 10.1016/j.ijantimicag.2007.10.023. View

20.

Carattoli A, Villa L, Poirel L, Bonnin R, Nordmann P . Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene. Antimicrob Agents Chemother. 2011; 56(2):783-6. PMC: 3264282. DOI: 10.1128/AAC.05116-11. View