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Initiating Head Development in Mouse Embryos: Integrating Signalling and Transcriptional Activity

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Journal Open Biol
Date 2012 Jul 4
PMID 22754658
Citations 27
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Abstract

The generation of an embryonic body plan is the outcome of inductive interactions between the progenitor tissues that underpin their specification, regionalization and morphogenesis. The intercellular signalling activity driving these processes is deployed in a time- and site-specific manner, and the signal strength must be precisely controlled. Receptor and ligand functions are modulated by secreted antagonists to impose a dynamic pattern of globally controlled and locally graded signals onto the tissues of early post-implantation mouse embryo. In response to the WNT, Nodal and Bone Morphogenetic Protein (BMP) signalling cascades, the embryo acquires its body plan, which manifests as differences in the developmental fate of cells located at different positions in the anterior-posterior body axis. The initial formation of the anterior (head) structures in the mouse embryo is critically dependent on the morphogenetic activity emanating from two signalling centres that are juxtaposed with the progenitor tissues of the head. A common property of these centres is that they are the source of antagonistic factors and the hub of transcriptional activities that negatively modulate the function of WNT, Nodal and BMP signalling cascades. These events generate the scaffold of the embryonic head by the early-somite stage of development. Beyond this, additional tissue interactions continue to support the growth, regionalization, differentiation and morphogenesis required for the elaboration of the structure recognizable as the embryonic head.

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References
1.
Rossant J, Tam P . Emerging asymmetry and embryonic patterning in early mouse development. Dev Cell. 2004; 7(2):155-64. DOI: 10.1016/j.devcel.2004.07.012. View

2.
Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K . Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development. 2005; 132(11):2535-46. DOI: 10.1242/dev.01844. View

3.
Mukhopadhyay M, Shtrom S, Chen L, Tsukui T, Gomer L, Dorward D . Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell. 2001; 1(3):423-34. DOI: 10.1016/s1534-5807(01)00041-7. View

4.
Tremblay K, Zaret K . Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev Biol. 2005; 280(1):87-99. DOI: 10.1016/j.ydbio.2005.01.003. View

5.
Miki R, Yoshida T, Murata K, Oki S, Kume K, Kume S . Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryos. Mech Dev. 2012; 128(11-12):597-609. DOI: 10.1016/j.mod.2011.12.004. View