» Articles » PMID: 8757128

Cerberus is a Head-inducing Secreted Factor Expressed in the Anterior Endoderm of Spemann's Organizer

Overview
Journal Nature
Specialty Science
Date 1996 Aug 15
PMID 8757128
Citations 137
Authors
Affiliations
Soon will be listed here.
Abstract

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

Citing Articles

Double assurance in the induction of axial development by egg dorsal determinants in embryos.

Azbazdar Y, De Robertis E Proc Natl Acad Sci U S A. 2025; 122(7):e2421772122.

PMID: 39928870 PMC: 11848351. DOI: 10.1073/pnas.2421772122.


Canonical and Non-Canonical Wnt Signaling Generates Molecular and Cellular Asymmetries to Establish Embryonic Axes.

Shi D J Dev Biol. 2024; 12(3).

PMID: 39189260 PMC: 11348223. DOI: 10.3390/jdb12030020.


Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease.

Hu L, Chen W, Qian A, Li Y Bone Res. 2024; 12(1):39.

PMID: 38987555 PMC: 11237130. DOI: 10.1038/s41413-024-00342-8.


The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.

Ermakova G, Kucheryavyy A, Zaraisky A, Bayramov A Int J Mol Sci. 2024; 25(4).

PMID: 38397089 PMC: 10889193. DOI: 10.3390/ijms25042412.


Understanding and manipulating extracellular behaviors of Wnt ligands.

Mii Y In Vitro Cell Dev Biol Anim. 2024; 60(5):441-448.

PMID: 38379096 DOI: 10.1007/s11626-024-00856-9.