MicroRNA-124 is a Subventricular Zone Neuronal Fate Determinant

Overview

Journal J Neurosci

Specialty Neurology

Date 2012 Jun 30

PMID 22745489

Citations 113

Authors

Malin Akerblom

Rohit Sachdeva

Isabelle Barde

Sonia Verp

Bernhard Gentner

Didier Trono

Johan Jakobsson

Affiliations

Soon will be listed here.

Abstract

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.

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