Johan Jakobsson
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Explore the profile of Johan Jakobsson including associated specialties, affiliations and a list of published articles.
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4973
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Recent Articles
1.
Christiansen J, Ferreira S, Szymkowski D, Jakobsson J, Tansey M, Romero-Ramos M
Neurobiol Dis
. 2025 Jan;
206:106803.
PMID: 39800228
The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play...
2.
Governa V, de Oliveira K, Bang-Rudenstam A, Offer S, Cerezo-Magana M, Li J, et al.
Sci Transl Med
. 2024 Oct;
16(771):eadk1168.
PMID: 39475570
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses...
3.
Jakobsson J, Burtin C, Hedlund M, Boraxbekk C, Westman J, Karalija N, et al.
Trials
. 2024 Oct;
25(1):664.
PMID: 39375781
Background: Beyond being a pulmonary disease, chronic obstructive pulmonary disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in the...
4.
Pandiloski N, Horvath V, Karlsson O, Koutounidou S, Dorazehi F, Christoforidou G, et al.
Nat Commun
. 2024 Aug;
15(1):7534.
PMID: 39214989
The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate...
5.
Gustavsson E, Sethi S, Gao Y, Brenton J, Garcia-Ruiz S, Zhang D, et al.
Sci Adv
. 2024 Jun;
10(26):eadk1296.
PMID: 38924406
Mutations in cause Gaucher disease and are the most important genetic risk factor for Parkinson's disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene,...
6.
Horvath V, Garza R, Jonsson M, Johansson P, Adami A, Christoforidou G, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(10):1543-1556.
PMID: 38834915
SVA (SINE (short interspersed nuclear element)-VNTR (variable number of tandem repeats)-Alu) retrotransposons remain active in humans and contribute to individual genetic variation. Polymorphic SVA alleles harbor gene regulatory potential and...
7.
Jakobsson J, Stoffels A, van Hees H, De Brandt J, Nyberg A, Klijn P
BMJ Open
. 2024 May;
14(5):e084296.
PMID: 38803267
Introduction: Chronic obstructive pulmonary disease (COPD) is a major global health concern, characterised by ventilatory constraints, decreased cardiovascular fitness and reduced limb muscle function, profoundly affecting patients' quality of life....
8.
Garza R, Sharma Y, Atacho D, Thiruvalluvan A, Abu Hamdeh S, Jonsson M, et al.
Cell Rep
. 2023 Nov;
42(11):113395.
PMID: 37967557
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used...
9.
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
Garza R, Atacho D, Adami A, Gerdes P, Vinod M, Hsieh P, et al.
Sci Adv
. 2023 Nov;
9(44):eadh9543.
PMID: 37910626
The genetic mechanisms underlying the expansion in size and complexity of the human brain remain poorly understood. Long interspersed nuclear element-1 (L1) retrotransposons are a source of divergent genetic information...
10.
Olfat S, Matlik K, Kopra J, Garton D, Iivanainen V, Bhattacharya D, et al.
eNeuro
. 2023 Jan;
10(2).
PMID: 36690469
Parkinson's disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons and...