Circular Proteins from Plants and Fungi

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2012 Jun 16

PMID 22700984

Citations 19

Authors

Ulf Goransson

Robert Burman

Sunithi Gunasekera

Adam A Stromstedt

K Johan Rosengren

Affiliations

Soon will be listed here.

Abstract

Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthesis, represent a novel class of natural products attracting increasing interest. From a scientific point of view, these compounds raise questions of where and why they occur in nature and how they are formed. From a rational point of view, these proteins and their structural concept may be exploited for crop protection and novel pharmaceuticals. Here, we review the current knowledge of three protein families: cyclotides and circular sunflower trypsin inhibitors from the kingdom of plants and the Amanita toxins from fungi. A particular emphasis is placed on their biological origin, structure, and activity. In addition, the opportunity for discovery of novel circular proteins and recent insights into their mechanism of action are discussed.

Citing Articles

Advances in cyclotide research: bioactivity to cyclotide-based therapeutics.

Grover A, Singh S, Sindhu S, Lath A, Kumar S Mol Divers. 2025; .

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Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro.

Melander E, Eriksson C, Wellens S, Hosseini K, Fredriksson R, Gosselet F Pharmaceutics. 2023; 15(5).

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Peptide Toxins as Biothreats and the Potential for AI Systems to Enhance Biosecurity.

Lee Y, Cowan A, Tankard A Front Bioeng Biotechnol. 2022; 10:860390.

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Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides.

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"Protein" no longer means what it used to.

Parisi G, Palopoli N, Tosatto S, Fornasari M, Tompa P Curr Res Struct Biol. 2021; 3:146-152.

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