Glucocorticoid-loaded Core-cross-linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2012 Jun 14

PMID 22692876

Citations 34

Authors

Bart J Crielaard

Cristianne J F Rijcken

Lingdong Quan

Steffen van der Wal

Isil Altintas

Martin van der Pot

John A W Kruijtzer

Rob M J Liskamp

Raymond M Schiffelers

Cornelus F van Nostrum

Wim E Hennink

Dong Wang

Twan Lammers

Gert Storm

Affiliations

Soon will be listed here.

Abstract

Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

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References

Kushner I, Somerville J . Permeability of human synovial membrane to plasma proteins. Relationship to molecular size and inflammation. Arthritis Rheum. 1971; 14(5):560-70. DOI: 10.1002/art.1780140503. View

Choi H, Ipe B, Misra P, Lee J, Bawendi M, Frangioni J . Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots. Nano Lett. 2009; 9(6):2354-9. PMC: 2782558. DOI: 10.1021/nl900872r. View

Wang D, Miller S, Sima M, Parker D, Buswell H, Goodrich K . The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res. 2004; 21(10):1741-9. DOI: 10.1023/b:pham.0000045232.18134.e9. View

Rijcken C, Veldhuis T, Ramzi A, Meeldijk J, van Nostrum C, Hennink W . Novel fast degradable thermosensitive polymeric micelles based on PEG-block-poly(N-(2-hydroxyethyl)methacrylamide-oligolactates). Biomacromolecules. 2005; 6(4):2343-51. DOI: 10.1021/bm0502720. View

Quan L, Purdue P, Liu X, Boska M, Lele S, Thiele G . Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. Arthritis Res Ther. 2010; 12(5):R170. PMC: 2990997. DOI: 10.1186/ar3130. View

Pike D, Ghandehari H . HPMA copolymer-cyclic RGD conjugates for tumor targeting. Adv Drug Deliv Rev. 2009; 62(2):167-83. DOI: 10.1016/j.addr.2009.11.027. View

Neumann E, Frei E, Funk D, Becker M, Schrenk H, Muller-Ladner U . Native albumin for targeted drug delivery. Expert Opin Drug Deliv. 2010; 7(8):915-25. DOI: 10.1517/17425247.2010.498474. View

Maeda H . Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug Chem. 2010; 21(5):797-802. DOI: 10.1021/bc100070g. View

Bae Y, Fukushima S, Harada A, Kataoka K . Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed Engl. 2003; 42(38):4640-3. DOI: 10.1002/anie.200250653. View

10.

Talelli M, Rijcken C, van Nostrum C, Storm G, Hennink W . Micelles based on HPMA copolymers. Adv Drug Deliv Rev. 2009; 62(2):231-9. DOI: 10.1016/j.addr.2009.11.029. View

11.

van Eden W, Thole J, van der Zee R, Noordzij A, van Embden J, Hensen E . Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature. 1988; 331(6152):171-3. DOI: 10.1038/331171a0. View

12.

Khachigian L . Collagen antibody-induced arthritis. Nat Protoc. 2007; 1(5):2512-6. DOI: 10.1038/nprot.2006.393. View

13.

Metselaar J, Wauben M, Wagenaar-Hilbers J, Boerman O, Storm G . Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum. 2003; 48(7):2059-66. DOI: 10.1002/art.11140. View

14.

Fitzgerald D, Wayne A, Kreitman R, Pastan I . Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Res. 2011; 71(20):6300-9. PMC: 3201758. DOI: 10.1158/0008-5472.CAN-11-1374. View

15.

Hoes J, Jacobs J, Buttgereit F, Bijlsma J . Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis. Nat Rev Rheumatol. 2010; 6(12):693-702. DOI: 10.1038/nrrheum.2010.179. View

16.

van Steenbergen M, Underberg W, Hennink W . Degradation kinetics of methacrylated dextrans in aqueous solution. J Pharm Sci. 1997; 86(4):413-7. DOI: 10.1021/js9604220. View

17.

Poon Z, Lee J, Morton S, Hammond P . Controlling in vivo stability and biodistribution in electrostatically assembled nanoparticles for systemic delivery. Nano Lett. 2011; 11(5):2096-103. PMC: 3124010. DOI: 10.1021/nl200636r. View

18.

Kopecek J, Kopeckova P . HPMA copolymers: origins, early developments, present, and future. Adv Drug Deliv Rev. 2009; 62(2):122-49. PMC: 2836498. DOI: 10.1016/j.addr.2009.10.004. View

19.

Schoenmakers R, van de Wetering P, Elbert D, Hubbell J . The effect of the linker on the hydrolysis rate of drug-linked ester bonds. J Control Release. 2004; 95(2):291-300. DOI: 10.1016/j.jconrel.2003.12.009. View

20.

Rijcken C, Snel C, Schiffelers R, van Nostrum C, Hennink W . Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials. 2007; 28(36):5581-93. DOI: 10.1016/j.biomaterials.2007.08.047. View