Tissue- and Organ-selective Biodistribution of NIR Fluorescent Quantum Dots

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2009 May 9

PMID 19422261

Citations 102

Authors

Hak Soo Choi

Binil Itty Ipe

Preeti Misra

Jeong Heon Lee

Moungi G Bawendi

John V Frangioni

Affiliations

Soon will be listed here.

Abstract

A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.

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