Enhancer Dysfunction: How the Main Regulators of Gene Expression Contribute to Cancer

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2012 May 25

PMID 22621675

Citations 5

Authors

Siavash K Kurdistani

Affiliations

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Abstract

A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.

Citing Articles

The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression.

Shao L, Zuo X, Yang Y, Zhang Y, Yang N, Shen B Genome Biol. 2019; 20(1):103.

PMID: 31126313 PMC: 6533720. DOI: 10.1186/s13059-019-1696-1.

Identification of strong intron enhancer in the heparanase gene: effect of functional rs4693608 variant on HPSE enhancer activity in hematological and solid malignancies.

Ostrovsky O, Grushchenko-Polaq A, Beider K, Mayorov M, Canaani J, Shimoni A Oncogenesis. 2018; 7(6):51.

PMID: 29955035 PMC: 6023935. DOI: 10.1038/s41389-018-0060-8.

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.

Rahnamoun H, Hong J, Sun Z, Lee J, Lu H, Lauberth S J Biol Chem. 2018; 293(34):13234-13246.

PMID: 29954944 PMC: 6109924. DOI: 10.1074/jbc.RA118.003387.

MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.

Sze C, Shilatifard A Cold Spring Harb Perspect Med. 2016; 6(11).

PMID: 27638352 PMC: 5088509. DOI: 10.1101/cshperspect.a026427.

Enhancer malfunction in cancer.

Herz H, Hu D, Shilatifard A Mol Cell. 2014; 53(6):859-66.

PMID: 24656127 PMC: 4049186. DOI: 10.1016/j.molcel.2014.02.033.

References

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