Treatment of One Case of Cerebral Palsy Combined with Posterior Visual Pathway Injury Using Autologous Bone Marrow Mesenchymal Stem Cells

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2012 May 22

PMID 22607263

Citations 13

Authors

Min Li

Aixue Yu

Fangfang Zhang

Guanghui Dai

Hongbin Cheng

Xiaodong Wang

Yihua An

Affiliations

Soon will be listed here.

Abstract

Background: Cerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9-30% of cerebral palsy patients are also visually impaired, for which no effective treatment is available. Bone marrow mesenchymal stem cells (BMSCs) have very strong self-renewal, proliferation, and pluripotent differentiation potentials. Therefore, autologous BMSC transplantation has become a novel method for treating cerebral palsy.

Methods: An 11-year-old boy had a clear history of dystocia and asphyxia after birth; at the age of 6 months, the family members observed that his gaze roamed and noted that he displayed a lack of attention. A brain MRI examination at the age of 7 years showed that the child had cerebral palsy with visual impairment (i.e., posterior visual pathway injury). The patient was hospitalized for 20 days and was given four infusions of intravenous autologous BMSCs. Before transplantation and 1, 6, and 12 months after transplantation, a visual evoked potential test, an electrocardiogram, routine blood tests, and liver and kidney function tests were performed.

Results: The patient did not have any adverse reactions during hospitalization or postoperative follow-up. After discharge, the patient could walk more smoothly than he could before transplantation; furthermore, his vision significantly improved 6 months after transplantation, which was also supported by the electrophysiological examinations.

Conclusions: The clinical application of BMSCs is effective for improving vision in a patient with cerebral palsy combined with visual impairment.

Citing Articles

A systematic review of cell therapy modalities and outcomes in cerebral palsy.

Akat A, Karaoz E Mol Cell Biochem. 2024; 480(2):891-922.

PMID: 39033213 DOI: 10.1007/s11010-024-05072-3.

Are We Getting It Right? A Scoping Review of Outcomes Reported in Cell Therapy Clinical Studies for Cerebral Palsy.

Finch-Edmondson M, Paton M, Honan I, Karlsson P, Stephenson C, Chiu D J Clin Med. 2022; 11(24).

PMID: 36555936 PMC: 9786692. DOI: 10.3390/jcm11247319.

Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review.

Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A Bosn J Basic Med Sci. 2021; 21(6):672-701.

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Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases.

Liem N, Huyen T, Huong L, Doan N, Anh B, Phuong Anh N Front Pediatr. 2020; 7:543.

PMID: 32039110 PMC: 6993568. DOI: 10.3389/fped.2019.00543.

Role of XIAP gene overexpressed bone marrow mesenchymal stem cells in the treatment of cerebral injury in rats with cerebral palsy.

Deng W, Fan C, Fang Y, Zhao Y, Wei Y, Li M Cancer Cell Int. 2019; 19:273.

PMID: 31660045 PMC: 6806515. DOI: 10.1186/s12935-019-0988-6.

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