Development of Humanized Mouse Models to Study Human Malaria Parasite Infection

Overview

Journal Future Microbiol

Specialties Infectious Diseases
Microbiology

Date 2012 May 10

PMID 22568719

Citations 26

Authors

Ashley M Vaughan

Stefan H I Kappe

Alexander Ploss

Sebastian A Mikolajczak

Affiliations

Soon will be listed here.

Abstract

Malaria is a disease caused by infection with Plasmodium parasites that are transmitted by mosquito bite. Five different species of Plasmodium infect humans with severe disease, but human malaria is primarily caused by Plasmodium falciparum. The burden of malaria on the developing world is enormous, and a fully protective vaccine is still elusive. One of the biggest challenges in the quest for the development of new antimalarial drugs and vaccines is the lack of accessible animal models to study P. falciparum infection because the parasite is restricted to the great apes and human hosts. Here, we review the current state of research in this field and provide an outlook of the development of humanized small animal models to study P. falciparum infection that will accelerate fundamental research into human parasite biology and could accelerate drug and vaccine design in the future.

Citing Articles

The human malaria- monkey model: a historical perspective in antimalarial chemotherapy research at the Gorgas Memorial Laboratory-Panama.

Obaldia 3rd N Antimicrob Agents Chemother. 2024; 68(7):e0033824.

PMID: 38837364 PMC: 11232403. DOI: 10.1128/aac.00338-24.

Myeloproliferative Neoplasms: Diseases Mediated by Chronic Activation of Signal Transducer and Activator of Transcription (STAT) Proteins.

Liongue C, Ward A Cancers (Basel). 2024; 16(2).

PMID: 38254802 PMC: 10813624. DOI: 10.3390/cancers16020313.

Using Cryopreserved Sporozoites in a Humanized Mouse Model to Study Early Malaria Infection Processes and Test Prophylactic Treatments.

Jimenez-Diaz M, Mohrle J, Angulo-Barturen I, Demarta-Gatsi C Microorganisms. 2023; 11(9).

PMID: 37764054 PMC: 10536749. DOI: 10.3390/microorganisms11092209.

Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages.

Huang W, Mabrouk M, Zhou L, Baba M, Tachibana M, Torii M Commun Biol. 2022; 5(1):773.

PMID: 35915227 PMC: 9341416. DOI: 10.1038/s42003-022-03688-z.

Parasite Viability as a Measure of Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.

Radohery G, Walz A, Gumpp C, Cherkaoui-Rbati M, Gobeau N, Gower J Antimicrob Agents Chemother. 2022; 66(7):e0011422.

PMID: 35727057 PMC: 9295577. DOI: 10.1128/aac.00114-22.

References

Legrand N, Huntington N, Nagasawa M, Bakker A, Schotte R, Strick-Marchand H . Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A. 2011; 108(32):13224-9. PMC: 3156191. DOI: 10.1073/pnas.1101398108. View

Cummings J, Spring M, Schwenk R, Ockenhouse C, Kester K, Polhemus M . Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection. Vaccine. 2009; 28(31):5135-44. DOI: 10.1016/j.vaccine.2009.08.046. View

Willinger T, Rongvaux A, Takizawa H, Yancopoulos G, Valenzuela D, Murphy A . Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A. 2011; 108(6):2390-5. PMC: 3038773. DOI: 10.1073/pnas.1019682108. View

MacKellar D, ONeill M, Aly A, Sacci Jr J, Cowman A, Kappe S . Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages. Eukaryot Cell. 2010; 9(5):784-94. PMC: 2863949. DOI: 10.1128/EC.00336-09. View

Brezillon N, DaSilva L, LHote D, Bernex F, Piquet J, Binart N . Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes. Cell Transplant. 2008; 17(7):803-12. DOI: 10.3727/096368908786516800. View

Badell E, Pasquetto V, Eling W, Thomas A, Druilhe P . Human Plasmodium liver stages in SCID mice: a feasible model?. Parasitol Today. 1995; 11(5):169-71. DOI: 10.1016/0169-4758(95)80147-2. View

Mazier D, Beaudoin R, Mellouk S, Druilhe P, Texier B, Trosper J . Complete development of hepatic stages of Plasmodium falciparum in vitro. Science. 1985; 227(4685):440-2. DOI: 10.1126/science.3880923. View

Bissig K, Wieland S, Tran P, Isogawa M, Le T, Chisari F . Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010; 120(3):924-30. PMC: 2827952. DOI: 10.1172/JCI40094. View

Huntington N, Legrand N, Alves N, Jaron B, Weijer K, Plet A . IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med. 2008; 206(1):25-34. PMC: 2626663. DOI: 10.1084/jem.20082013. View

10.

Jimenez-Diaz M, Mulet T, Gomez V, Viera S, Alvarez A, Garuti H . Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence. Cytometry A. 2008; 75(3):225-35. DOI: 10.1002/cyto.a.20647. View

11.

Sacci Jr J, Alam U, Douglas D, Lewis J, Tyrrell D, Azad A . Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. Int J Parasitol. 2006; 36(3):353-60. DOI: 10.1016/j.ijpara.2005.10.014. View

12.

Greenwood B, Fidock D, Kyle D, Kappe S, Alonso P, Collins F . Malaria: progress, perils, and prospects for eradication. J Clin Invest. 2008; 118(4):1266-76. PMC: 2276780. DOI: 10.1172/JCI33996. View

13.

Moore J, Kumar N, Shultz L, Rajan T . Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes. J Exp Med. 1995; 181(6):2265-70. PMC: 2192049. DOI: 10.1084/jem.181.6.2265. View

14.

Jimenez-Diaz M, Mulet T, Viera S, Gomez V, Garuti H, Ibanez J . Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes. Antimicrob Agents Chemother. 2009; 53(10):4533-6. PMC: 2764183. DOI: 10.1128/AAC.00519-09. View

15.

Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, van Rooijen N . Liver-stage development of Plasmodium falciparum, in a humanized mouse model. J Infect Dis. 2006; 193(7):996-1004. DOI: 10.1086/500840. View

16.

Legrand N, Ploss A, Balling R, Becker P, Borsotti C, Brezillon N . Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe. 2009; 6(1):5-9. PMC: 7038630. DOI: 10.1016/j.chom.2009.06.006. View

17.

Heckel J, Sandgren E, Degen J, Palmiter R, Brinster R . Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell. 1990; 62(3):447-56. DOI: 10.1016/0092-8674(90)90010-c. View

18.

Spielmann T, Fergusen D, Beck H . etramps, a new Plasmodium falciparum gene family coding for developmentally regulated and highly charged membrane proteins located at the parasite-host cell interface. Mol Biol Cell. 2003; 14(4):1529-44. PMC: 153120. DOI: 10.1091/mbc.e02-04-0240. View

19.

Sandgren E, Palmiter R, Heckel J, Daugherty C, Brinster R, Degen J . Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell. 1991; 66(2):245-56. DOI: 10.1016/0092-8674(91)90615-6. View

20.

VanBuskirk K, ONeill M, De La Vega P, Maier A, Krzych U, Williams J . Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A. 2009; 106(31):13004-9. PMC: 2714279. DOI: 10.1073/pnas.0906387106. View