The Anaphase-promoting Complex or Cyclosome Supports Cell Survival in Response to Endoplasmic Reticulum Stress

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Apr 28

PMID 22539978

Citations 4

Authors

Meifan Chen

Gustavo J Gutierrez

Zeev A Ronai

Affiliations

Soon will be listed here.

Abstract

The anaphase-promoting complex or cyclosome (APC/C) is a multi-subunit ubiquitin ligase that regulates exit from mitosis and G1 phase of the cell cycle. Although the regulation and function of APC/C(Cdh1) in the unperturbed cell cycle is well studied, little is known of its role in non-genotoxic stress responses. Here, we demonstrate the role of APC/C(Cdh1) (APC/C activated by Cdh1 protein) in cellular protection from endoplasmic reticulum (ER) stress. Activation of APC/C(Cdh1) under ER stress conditions is evidenced by Cdh1-dependent degradation of its substrates. Importantly, the activity of APC/C(Cdh1) maintains the ER stress checkpoint, as depletion of Cdh1 by RNAi impairs cell cycle arrest and accelerates cell death following ER stress. Our findings identify APC/C(Cdh1) as a regulator of cell cycle checkpoint and cell survival in response to proteotoxic insults.

Citing Articles

The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator.

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Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress.

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A structural model of the anaphase promoting complex co-activator (Cdh1) and in silico design of inhibitory compounds.

Rahimi H, Negahdari B, Shokrgozar M, Madadkar-Sobhani A, Mahdian R, Foroumadi A Res Pharm Sci. 2015; 10(1):59-67.

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