Evidence of Early Involvement of Apoptosis Inducing Factor-induced Neuronal Death in Alzheimer Brain

Overview

Journal Anat Cell Biol

Specialty Anatomy & Histology

Date 2012 Apr 27

PMID 22536549

Citations 17

Authors

Ji-Hye Lee

Young-Hee Cheon

Ran-Sook Woo

Dae-Yong Song

Cheil Moon

Tai-Kyoung Baik

Affiliations

Soon will be listed here.

Abstract

Apoptosis inducing factor (AIF) has been proposed to act as a putative reactive oxygen species scavenger in mitochondria. When apoptotic cell death is triggered, AIF translocates to the nucleus, where it leads to nuclear chromatin condensation and large-scale DNA fragmentation which result in caspase-independent neuronal death. We performed this study to investigate the possibility that, in addition to caspase-dependent neuronal death, AIF induced neuronal death could be a cause of neuronal death in Alzheimer's disease (AD). We have found that AIF immunoreactivity was increased in the hippocampal pyramidal neurons in the Alzheimer brains compared to those of healthy, age-matched control brains. Nuclear AIF immunoreactivity was detected in the apoptotic pyramidal CA1 neurons at the early stage of AD and CA2 at the advanced stage. Nuclear AIF positive neurons were also observed in the amygdala and cholinergic neurons of the basal forebrain (BFCN) from the early stages of AD. The results of this study imply that AIF-induced apoptosis may contribute to neuronal death within the hippocampus, amygdala, and BFCN in early of AD.

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References

Stadelmann C, Deckwerth T, Srinivasan A, Bancher C, Bruck W, Jellinger K . Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol. 1999; 155(5):1459-66. PMC: 1866960. DOI: 10.1016/S0002-9440(10)65460-0. View

Mudher A, Lovestone S . Alzheimer's disease-do tauists and baptists finally shake hands?. Trends Neurosci. 2002; 25(1):22-6. DOI: 10.1016/s0166-2236(00)02031-2. View

Zhang X, Chen J, Graham S, Du L, Kochanek P, Draviam R . Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem. 2002; 82(1):181-91. DOI: 10.1046/j.1471-4159.2002.00975.x. View

Takuma H, Tomiyama T, Kuida K, Mori H . Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. J Neuropathol Exp Neurol. 2004; 63(3):255-61. DOI: 10.1093/jnen/63.3.255. View

Nunomura A, Chiba S . Avoidance of Apoptosis in Alzheimer's Disease. J Alzheimers Dis. 2002; 2(1):59-60. DOI: 10.3233/jad-2000-2107. View

Beal M . Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr. 2004; 36(4):381-6. DOI: 10.1023/B:JOBB.0000041772.74810.92. View

Nunomura A, Perry G, Pappolla M, Wade R, Hirai K, Chiba S . RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci. 1999; 19(6):1959-64. PMC: 6782583. View

Wang H, Yu S, Koh D, Lew J, Coombs C, Bowers W . Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci. 2004; 24(48):10963-73. PMC: 6730219. DOI: 10.1523/JNEUROSCI.3461-04.2004. View

Otera H, Ohsakaya S, Nagaura Z, Ishihara N, Mihara K . Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J. 2005; 24(7):1375-86. PMC: 1142539. DOI: 10.1038/sj.emboj.7600614. View

10.

Evan G, Vousden K . Proliferation, cell cycle and apoptosis in cancer. Nature. 2001; 411(6835):342-8. DOI: 10.1038/35077213. View

11.

Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo E . Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 2002; 82(2):283-94. DOI: 10.1046/j.1471-4159.2002.00970.x. View

12.

Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj E . Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol. 2001; 60(8):759-67. DOI: 10.1093/jnen/60.8.759. View

13.

Pratico D, Uryu K, Leight S, Trojanoswki J, Lee V . Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci. 2001; 21(12):4183-7. PMC: 6762743. View

14.

Jellinger K . Cell death mechanisms in neurodegeneration. J Cell Mol Med. 2002; 5(1):1-17. PMC: 6737760. DOI: 10.1111/j.1582-4934.2001.tb00134.x. View

15.

Woo R, Lee J, Yu H, Song D, Baik T . Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP/PS1 mice, a model of Alzheimer's disease. Anat Cell Biol. 2011; 44(2):116-27. PMC: 3145840. DOI: 10.5115/acb.2011.44.2.116. View

16.

Klein J, Longo-Guess C, Rossmann M, Seburn K, Hurd R, Frankel W . The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature. 2002; 419(6905):367-74. DOI: 10.1038/nature01034. View

17.

Hardy J, Selkoe D . The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002; 297(5580):353-6. DOI: 10.1126/science.1072994. View

18.

Whitehouse P, Price D, Struble R, CLARK A, Coyle J, Delon M . Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science. 1982; 215(4537):1237-9. DOI: 10.1126/science.7058341. View

19.

HOPPER M, Vogel F . The limbic system in Alzheimer's disease. A neuropathologic investigation. Am J Pathol. 1976; 85(1):1-20. PMC: 2032549. View

20.

Emre M, Heckers S, Mash D, Geula C, Mesulam M . Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease. J Comp Neurol. 1993; 336(1):117-34. DOI: 10.1002/cne.903360110. View