Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer's Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Feb 26

PMID 35216107

Authors

Emanuela Paduraru

Diana Iacob

Viorica Rarinca

Angelica Rusu

Roxana Jijie

Ovidiu-Dumitru Ilie

Alin Ciobica

Mircea Nicoara

Bogdan Doroftei

Affiliations

Soon will be listed here.

Abstract

Mercury (Hg) is considered one of the most widespread toxic environmental pollutants, which seems to have multiple effects on organisms even at low concentrations. It has a critical role in many health problems with harmful consequences, with Hg primarily targeting the brain and its components, such as the central nervous system (CNS). Hg exposure was associated with numerous CNS disorders that frequently trigger Alzheimer's disease (AD). Patients with AD have higher concentrations of Hg in blood and brain tissue. This paper aims to emphasize a correlation between Hg and AD based on the known literature in the occupational field. The outcome shows that all these concerning elements could get attributed to Hg. However, recent studies did not investigate the molecular level of Hg exposure in AD. The present review highlights the interactions between Hg and AD in neuronal degenerations, apoptosis, autophagy, oxidative stress (OS), mitochondrial malfunctions, gastrointestinal (GI) microflora, infertility and altering gene expression.

Citing Articles

Promising the potential of β-caryophyllene on mercury chloride-induced alteration in cerebellum and spinal cord of young Wistar albino rats.

Yahyazadeh A, Gur F Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(12):10175-10189.

PMID: 38995373 PMC: 11582159. DOI: 10.1007/s00210-024-03268-4.

Neuroprotective Strategies and Cell-Based Biomarkers for Manganese-Induced Toxicity in Human Neuroblastoma (SH-SY5Y) Cells.

Cahill C, Sarang S, Bakshi R, Xia N, Lahiri D, Rogers J Biomolecules. 2024; 14(6).

PMID: 38927051 PMC: 11201412. DOI: 10.3390/biom14060647.

Food contamination and cardiovascular disease: a narrative review.

Mancuso G, Violi F, Nocella C Intern Emerg Med. 2024; 19(6):1693-1703.

PMID: 38743129 PMC: 11405437. DOI: 10.1007/s11739-024-03610-x.

Trace Elements in Alzheimer's Disease and Dementia: The Current State of Knowledge.

Tyczynska M, Gedek M, Brachet A, Strek W, Flieger J, Teresinski G J Clin Med. 2024; 13(8).

PMID: 38673657 PMC: 11050856. DOI: 10.3390/jcm13082381.

Mechanistic Evidence for Hg Removal from Wastewater by Biologically Produced Sulfur.

Jeong S, Park B, Yoon J, Kirkham M, Yang J, Kim H Toxics. 2024; 12(4).

PMID: 38668501 PMC: 11053473. DOI: 10.3390/toxics12040278.

References

Lanza Cariccio V, Sama A, Bramanti P, Mazzon E . Mercury Involvement in Neuronal Damage and in Neurodegenerative Diseases. Biol Trace Elem Res. 2018; 187(2):341-356. DOI: 10.1007/s12011-018-1380-4. View

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D . Oxidative stress, aging, and diseases. Clin Interv Aging. 2018; 13:757-772. PMC: 5927356. DOI: 10.2147/CIA.S158513. View

Lin X, Zhao J, Zhang W, He L, Wang L, Chang D . Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats. Ecotoxicol Environ Saf. 2020; 190:110130. DOI: 10.1016/j.ecoenv.2019.110130. View

Yorifuji T, Kashima S, Suryadhi M, Abudureyimu K . Temporal trends of infant and birth outcomes in Minamata after severe methylmercury exposure. Environ Pollut. 2017; 231(Pt 2):1586-1592. DOI: 10.1016/j.envpol.2017.09.060. View

ODonoghue J, Watson G, Brewer R, Zareba G, Eto K, Takahashi H . Neuropathology associated with exposure to different concentrations and species of mercury: A review of autopsy cases and the literature. Neurotoxicology. 2020; 78:88-98. PMC: 7217745. DOI: 10.1016/j.neuro.2020.02.011. View

Yin Z, Jiang H, Syversen T, Rocha J, Farina M, Aschner M . The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem. 2008; 107(4):1083-90. PMC: 2581650. DOI: 10.1111/j.1471-4159.2008.05683.x. View

Olivieri G, Brack C, Muller-Spahn F, Stahelin H, Herrmann M, Renard P . Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells. J Neurochem. 2000; 74(1):231-6. DOI: 10.1046/j.1471-4159.2000.0740231.x. View

Feitosa-Santana C, Bimler D, Paramei G, Oiwa N, Barboni M, Costa M . Color-space distortions following long-term occupational exposure to mercury vapor. Ophthalmic Physiol Opt. 2010; 30(5):724-30. DOI: 10.1111/j.1475-1313.2010.00764.x. View

Dong W, Liu J, Wei L, Jingfeng Y, Chernick M, Hinton D . Developmental toxicity from exposure to various forms of mercury compounds in medaka fish (Oryzias latipes) embryos. PeerJ. 2016; 4:e2282. PMC: 5012308. DOI: 10.7717/peerj.2282. View

10.

Hassan S, Moussa E, Abbott L . The effect of methylmercury exposure on early central nervous system development in the zebrafish (Danio rerio) embryo. J Appl Toxicol. 2011; 32(9):707-13. DOI: 10.1002/jat.1675. View

11.

Kayias E, Drosos G, Hapsas D, Anagnostopoulou G . Elemental mercury-induced subcutaneous granuloma. A case report and review of the literature. Acta Orthop Belg. 2003; 69(3):280-4. View

12.

Chakraborty P . Mercury exposure and Alzheimer's disease in India - An imminent threat?. Sci Total Environ. 2017; 589:232-235. DOI: 10.1016/j.scitotenv.2017.02.168. View

13.

Fujimura M, Usuki F . In situ different antioxidative systems contribute to the site-specific methylmercury neurotoxicity in mice. Toxicology. 2017; 392:55-63. DOI: 10.1016/j.tox.2017.10.004. View

14.

Jiang P, Mizushima N . Autophagy and human diseases. Cell Res. 2013; 24(1):69-79. PMC: 3879707. DOI: 10.1038/cr.2013.161. View

15.

Yuntao F, Chenjia G, Panpan Z, Wenjun Z, Suhua W, Guangwei X . Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes. Arch Toxicol. 2014; 90(2):333-45. PMC: 5029794. DOI: 10.1007/s00204-014-1425-1. View

16.

Milioni A, Nagy B, Moura A, Zachi E, Barboni M, Ventura D . Neurotoxic impact of mercury on the central nervous system evaluated by neuropsychological tests and on the autonomic nervous system evaluated by dynamic pupillometry. Neurotoxicology. 2016; 59:263-269. DOI: 10.1016/j.neuro.2016.04.010. View

17.

Parks J, Johs A, Podar M, Bridou R, Hurt Jr R, Smith S . The genetic basis for bacterial mercury methylation. Science. 2013; 339(6125):1332-5. DOI: 10.1126/science.1230667. View

18.

Zahir F, Rizwi S, Haq S, Khan R . Low dose mercury toxicity and human health. Environ Toxicol Pharmacol. 2011; 20(2):351-60. DOI: 10.1016/j.etap.2005.03.007. View

19.

Owoeye O, Arinola G . A Vegetable, Launaea taraxacifolia, Mitigated Mercuric Chloride Alteration of the Microanatomy of Rat Brain. J Diet Suppl. 2017; 14(6):613-625. DOI: 10.1080/19390211.2017.1288194. View

20.

de Souza A, de Carvalho A . Images in clinical medicine. Metallic mercury embolism to the hand. N Engl J Med. 2009; 360(5):507. DOI: 10.1056/NEJMicm040265. View