Hollow Silica and Silica-boron Nano/microparticles for Contrast-enhanced Ultrasound to Detect Small Tumors

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2012 Apr 14

PMID 22498299

Citations 33

Authors

Alexander Liberman

H Paul Martinez

Casey N Ta

Christopher V Barback

Robert F Mattrey

Yuko Kono

Sarah L Blair

William C Trogler

Andrew C Kummel

Zhe Wu

Affiliations

Soon will be listed here.

Abstract

Diagnosing tumors at an early stage when they are easily curable and may not require systemic chemotherapy remains a challenge to clinicians. In order to improve early cancer detection, gas filled hollow boron-doped silica particles have been developed, which can be used for ultrasound-guided breast conservation therapy. The particles are synthesized using a polystyrene template and subsequently calcinated to create hollow, rigid nanoporous microspheres. The microshells are filled with perfluoropentane vapor. Studies were performed in phantoms to optimize particle concentration, injection dose, and the ultrasound settings such as pulse frequency and mechanical index. In vitro studies have shown that these particles can be continuously imaged by US up to 48 min and their signal lifetime persisted for 5 days. These particles could potentially be given by intravenous injection and, in conjunction with contrast-enhanced ultrasound, be utilized as a screening tool to detect smaller breast cancers before they are detectible by traditional mammography.

Citing Articles

Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer.

Wrede P, Aghakhani A, Bozuyuk U, Yildiz E, Sitti M ACS Appl Mater Interfaces. 2023; .

PMID: 37917969 PMC: 10658455. DOI: 10.1021/acsami.3c11656.

Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.

Guo Y, Yang W, Pu G, Zhu C, Zhu Y, Li J J Nanobiotechnology. 2022; 20(1):316.

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Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications.

Kankala R, Han Y, Xia H, Wang S, Chen A J Nanobiotechnology. 2022; 20(1):126.

PMID: 35279150 PMC: 8917689. DOI: 10.1186/s12951-022-01315-x.

Targeted Phototherapy by Niobium Carbide for Mammalian Tumor Models Similar to Humans.

Liu Z, Jiang S, Tian Y, Shang H, Chen K, Tan H Front Oncol. 2022; 12:827171.

PMID: 35223508 PMC: 8866440. DOI: 10.3389/fonc.2022.827171.

The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery.

Qi S, Wang X, Chang K, Shen W, Yu G, Du J J Nanobiotechnology. 2022; 20(1):24.

PMID: 34991595 PMC: 8740484. DOI: 10.1186/s12951-021-01232-5.

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