A Spectral Fiedler Field-based Contrast Platform for Imaging of Nanoparticles in Colon Tumor

Overview

Journal Sci Rep

Specialty Science

Date 2018 Aug 1

PMID 30061558

Citations 1

Authors

Chenang Liu

Ankur Kapoor

Joshua VanOsdol

Kalyani Ektate

Zhenyu Kong

Ashish Ranjan

Affiliations

Soon will be listed here.

Abstract

The temporal and spatial patterns of nanoparticle that ferry both imaging and therapeutic agent in solid tumors is significantly influenced by target tissue movement, low spatial resolution, and inability to accurately define regions of interest (ROI) at certain tissue depths. These combine to limit and define nanoparticle untreated regions in tumors. Utilizing graph and matrix theories, the objective of this project was to develop a novel spectral Fiedler field (SFF) based-computational technology for nanoparticle mapping in tumors. The novelty of SFF lies in the utilization of the changes in the tumor topology from baseline for contrast variation assessment. Data suggest that SFF can enhance the spatiotemporal contrast compared to conventional method by 2-3 folds in tumors. Additionally, the SFF contrast is readily translatable for assessment of tumor drug distribution. Thus, our SFF computational platform has the potential for integration into devices that allow contrast and drug delivery applications.

Citing Articles

Computational Approaches in Theranostics: Mining and Predicting Cancer Data.

Cova T, Bento D, Nunes S Pharmaceutics. 2019; 11(3).

PMID: 30871264 PMC: 6471740. DOI: 10.3390/pharmaceutics11030119.

References

Liberman A, Martinez H, Ta C, Barback C, Mattrey R, Kono Y . Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors. Biomaterials. 2012; 33(20):5124-9. PMC: 3588157. DOI: 10.1016/j.biomaterials.2012.03.066. View

Chen G, Wang K, Zhou Y, Ding L, Ullah A, Hu Q . Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy. ACS Appl Mater Interfaces. 2016; 8(38):25087-95. DOI: 10.1021/acsami.6b07425. View

Kwon I, Lee S, Han B, Park K . Analysis on the current status of targeted drug delivery to tumors. J Control Release. 2012; 164(2):108-14. PMC: 3833679. DOI: 10.1016/j.jconrel.2012.07.010. View

Sen A, Capitano M, Spernyak J, Schueckler J, Thomas S, Singh A . Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Res. 2011; 71(11):3872-80. PMC: 3184616. DOI: 10.1158/0008-5472.CAN-10-4482. View

de Smet M, Hijnen N, Langereis S, Elevelt A, Heijman E, Dubois L . Magnetic resonance guided high-intensity focused ultrasound mediated hyperthermia improves the intratumoral distribution of temperature-sensitive liposomal doxorubicin. Invest Radiol. 2013; 48(6):395-405. DOI: 10.1097/RLI.0b013e3182806940. View

Jo S, Ku S, Won Y, Kim S, Kwon I . Targeted Nanotheranostics for Future Personalized Medicine: Recent Progress in Cancer Therapy. Theranostics. 2016; 6(9):1362-77. PMC: 4924505. DOI: 10.7150/thno.15335. View

Min H, You D, Son S, Jeon S, Park J, Lee S . Echogenic Glycol Chitosan Nanoparticles for Ultrasound-Triggered Cancer Theranostics. Theranostics. 2015; 5(12):1402-18. PMC: 4672021. DOI: 10.7150/thno.13099. View

Davis R, Viglianti B, Yarmolenko P, Park J, Stauffer P, Needham D . A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia. 2013; 29(6):569-81. PMC: 3779909. DOI: 10.3109/02656736.2013.790091. View

Stapleton S, Mirmilshteyn D, Zheng J, Allen C, Jaffray D . Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors. J Vis Exp. 2016; (114). PMC: 5091925. DOI: 10.3791/54226. View

10.

Ibsen S, Benchimol M, Simberg D, Schutt C, Steiner J, Esener S . A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. J Control Release. 2011; 155(3):358-66. PMC: 3196035. DOI: 10.1016/j.jconrel.2011.06.032. View

11.

Senavirathna L, Fernando R, Maples D, Zheng Y, Polf J, Ranjan A . Tumor Spheroids as an in vitro model for determining the therapeutic response to proton beam radiotherapy and thermally sensitive nanocarriers. Theranostics. 2013; 3(9):687-91. PMC: 3767115. DOI: 10.7150/thno.6381. View

12.

Leblond F, Davis S, Valdes P, Pogue B . Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications. J Photochem Photobiol B. 2009; 98(1):77-94. PMC: 3678966. DOI: 10.1016/j.jphotobiol.2009.11.007. View

13.

Rapoport N . Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012; 4(5):492-510. PMC: 3482424. DOI: 10.1002/wnan.1176. View

14.

Arranja A, Pathak V, Lammers T, Shi Y . Tumor-targeted nanomedicines for cancer theranostics. Pharmacol Res. 2016; 115:87-95. PMC: 5412956. DOI: 10.1016/j.phrs.2016.11.014. View

15.

Allen T, Cullis P . Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev. 2012; 65(1):36-48. DOI: 10.1016/j.addr.2012.09.037. View

16.

Negussie A, Yarmolenko P, Partanen A, Ranjan A, Jacobs G, Woods D . Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. Int J Hyperthermia. 2011; 27(2):140-55. PMC: 3417228. DOI: 10.3109/02656736.2010.528140. View

17.

Ektate K, Kapoor A, Maples D, Tuysuzoglu A, VanOsdol J, Ramasami S . Motion Compensated Ultrasound Imaging Allows Thermometry and Image Guided Drug Delivery Monitoring from Echogenic Liposomes. Theranostics. 2016; 6(11):1963-74. PMC: 4997249. DOI: 10.7150/thno.15922. View

18.

VanOsdol J, Ektate K, Ramasamy S, Maples D, Collins W, Malayer J . Sequential HIFU heating and nanobubble encapsulation provide efficient drug penetration from stealth and temperature sensitive liposomes in colon cancer. J Control Release. 2017; 247:55-63. PMC: 5293599. DOI: 10.1016/j.jconrel.2016.12.033. View

19.

Chakravarty R, Hong H, Cai W . Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature. Curr Drug Targets. 2014; 16(6):592-609. PMC: 4346511. DOI: 10.2174/1389450115666140902125657. View

20.

Omata D, Negishi Y, Suzuki R, Oda Y, Endo-Takahashi Y, Maruyama K . Nonviral gene delivery systems by the combination of bubble liposomes and ultrasound. Adv Genet. 2015; 89:25-48. DOI: 10.1016/bs.adgen.2014.11.001. View