Regulation of Frontline Antibody Responses by Innate Immune Signals

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2012 Apr 6

PMID 22477522

Citations 7

Authors

Alejo Chorny

Irene Puga

Andrea Cerutti

Affiliations

Soon will be listed here.

Abstract

Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T-cell-independent pathway for B-cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly "frontline" B cells located in the marginal zone of the spleen and in the intestine.

Citing Articles

Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy.

Furiness K, El Ansari Y, Oettgen H, Kanagaratham C Front Allergy. 2024; 5:1389669.

PMID: 38919913 PMC: 11196826. DOI: 10.3389/falgy.2024.1389669.

Mouse IgA modulates human gut microbiota with inflammatory bowel disease patients.

Takahashi K, Morita N, Tamano R, Gao P, Iida N, Andoh A J Gastroenterol. 2024; 59(9):812-824.

PMID: 38874761 PMC: 11339086. DOI: 10.1007/s00535-024-02121-y.

Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers.

Zhong Z, Nan K, Weng M, Yue Y, Zhou W, Wang Z Front Immunol. 2021; 12:765044.

PMID: 34868013 PMC: 8640120. DOI: 10.3389/fimmu.2021.765044.

Mucosal immunity to poliovirus.

Connor R, Brickley E, Wieland-Alter W, Ackerman M, Weiner J, Modlin J Mucosal Immunol. 2021; 15(1):1-9.

PMID: 34239028 PMC: 8732262. DOI: 10.1038/s41385-021-00428-0.

Intestinal IgA as a modulator of the gut microbiota.

Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S Gut Microbes. 2017; 8(5):486-492.

PMID: 28384049 PMC: 5628655. DOI: 10.1080/19490976.2017.1310357.

References

Medzhitov R . Toll-like receptors and innate immunity. Nat Rev Immunol. 2002; 1(2):135-45. DOI: 10.1038/35100529. View

Bouskra D, Brezillon C, Berard M, Werts C, Varona R, Gomperts Boneca I . Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. 2008; 456(7221):507-10. DOI: 10.1038/nature07450. View

Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace W . The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010; 33(1):71-83. DOI: 10.1016/j.immuni.2010.07.003. View

Cerutti A, Chen K, Chorny A . Immunoglobulin responses at the mucosal interface. Annu Rev Immunol. 2011; 29:273-93. PMC: 3064559. DOI: 10.1146/annurev-immunol-031210-101317. View

He B, Xu W, Santini P, Polydorides A, Chiu A, Estrella J . Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity. 2007; 26(6):812-26. DOI: 10.1016/j.immuni.2007.04.014. View

Pasare C, Medzhitov R . Toll-dependent control mechanisms of CD4 T cell activation. Immunity. 2004; 21(5):733-41. DOI: 10.1016/j.immuni.2004.10.006. View

Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T . Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat Immunol. 2011; 12(3):264-70. DOI: 10.1038/ni.1991. View

Sokol C, Barton G, Farr A, Medzhitov R . A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008; 9(3):310-8. PMC: 3888112. DOI: 10.1038/ni1558. View

Nathan C . Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol. 2006; 6(3):173-82. DOI: 10.1038/nri1785. View

10.

Cerutti A, Puga I, Cols M . Innate control of B cell responses. Trends Immunol. 2011; 32(5):202-11. PMC: 3090458. DOI: 10.1016/j.it.2011.02.004. View

11.

Cerutti A, Rescigno M . The biology of intestinal immunoglobulin A responses. Immunity. 2008; 28(6):740-50. PMC: 3057455. DOI: 10.1016/j.immuni.2008.05.001. View

12.

Uematsu S, Fujimoto K, Jang M, Yang B, Jung Y, Nishiyama M . Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008; 9(7):769-76. DOI: 10.1038/ni.1622. View

13.

Litinskiy M, Nardelli B, Hilbert D, He B, Schaffer A, Casali P . DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol. 2002; 3(9):822-9. PMC: 4621779. DOI: 10.1038/ni829. View

14.

Shang L, Fukata M, Thirunarayanan N, Martin A, Arnaboldi P, Maussang D . Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology. 2008; 135(2):529-38. PMC: 2598776. DOI: 10.1053/j.gastro.2008.04.020. View

15.

Martin F, Kearney J . Marginal-zone B cells. Nat Rev Immunol. 2002; 2(5):323-35. DOI: 10.1038/nri799. View

16.

Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O . Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med. 2011; 17(12):1585-93. PMC: 3902046. DOI: 10.1038/nm.2505. View

17.

Colino J, Shen Y, Snapper C . Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms. J Exp Med. 2002; 195(1):1-13. PMC: 2196017. DOI: 10.1084/jem.20011432. View

18.

Casola S, Otipoby K, Alimzhanov M, Humme S, Uyttersprot N, Kutok J . B cell receptor signal strength determines B cell fate. Nat Immunol. 2004; 5(3):317-27. DOI: 10.1038/ni1036. View

19.

Wykes M, Pombo A, Jenkins C, MacPherson G . Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J Immunol. 1998; 161(3):1313-9. View

20.

Macpherson A, Harris N . Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004; 4(6):478-85. DOI: 10.1038/nri1373. View