Intestinal IgA As a Modulator of the Gut Microbiota

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2017 Apr 7

PMID 28384049

Citations 39

Authors

Shinsaku Okai

Fumihito Usui

Misa Ohta

Hiroshi Mori

Ken Kurokawa

Satoshi Matsumoto

Tamotsu Kato

Eiji Miyauchi

Hiroshi Ohno

Reiko Shinkura

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence suggests that dysbiosis plays a role in the pathogenesis of intestinal diseases including inflammatory bowel disease (IBD) as well as extra-intestinal disorders. As a modulator of the intestinal microbiota, we isolated a mouse monoclonal IgA antibody (clone W27) with high affinities for multiple commensal bacteria, but not for beneficial bacteria such as Lactobacillus casei (L. casei). Via specific recognition of an epitope in serine hydroxymethyltransferase (SHMT), a bacterial metabolic enzyme, W27 IgA selectively inhibited the in vitro growth of bound bacteria, including Escherichia coli (E. coli), while having no effect on unbound beneficial bacteria such as L. casei. By modulating the gut microbiota in vivo, oral administration of W27 IgA effectively prevented development of colitis in several mouse models. Here we discuss how intestinal IgA modulates the gut microbiota through recognition of SHMT.

Citing Articles

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Role of mucosal IgA antibodies as novel therapies to enhance mucosal barriers.

Gao P, Morita N, Shinkura R Semin Immunopathol. 2024; 47(1):1.

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Mouse IgA modulates human gut microbiota with inflammatory bowel disease patients.

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