Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2003 Oct 24

PMID 14573789

Citations 679

Authors

Michael Z Michael

Susan M O Connor

Nicholas G van Holst Pellekaan

Graeme P Young

Robert J James

Affiliations

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Abstract

Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.

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