Regulation of Ferroptosis by Non-Coding RNAs in Head and Neck Cancers

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 25

PMID 35328568

Authors

Pei-Ling Hsieh

Shih-Chi Chao

Pei-Ming Chu

Cheng-Chia Yu

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a newly identified mode of programmed cell death characterized by iron-associated accumulation of lipid peroxides. Emerging research on ferroptosis has suggested its implication in tumorigenesis and stemness of cancer. On the other hand, non-coding RNAs have been shown to play a pivotal role in the modulation of various genes that affect the progression of cancer cells and ferroptosis. In this review, we summarize recent advances in the theoretical modeling of ferroptosis and its relationship between non-coding RNAs and head and neck cancers. Aside from the significance of ferroptosis-related non-coding RNAs in prognostic relevance, we also review how these non-coding RNAs participate in the regulation of iron, lipid metabolism, and reactive oxygen species accumulation. We aim to provide a thorough grounding in the function of ferroptosis-related non-coding RNAs based on current knowledge in an effort to develop effective therapeutic strategies for head and neck cancers.

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References

Zhang Y, Xu Z . miR-93 enhances cell proliferation by directly targeting CDKN1A in nasopharyngeal carcinoma. Oncol Lett. 2018; 15(2):1723-1727. PMC: 5774441. DOI: 10.3892/ol.2017.7492. View

Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C . Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2020; 318(3):H508-H518. DOI: 10.1152/ajpheart.00559.2019. View

Yu C, Hu F, Yu C, Chou M . Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cells. Head Neck. 2014; 38 Suppl 1:E231-8. DOI: 10.1002/hed.23975. View

Scapoli L, Palmieri A, Lo Muzio L, Pezzetti F, Rubini C, Girardi A . MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression. Int J Immunopathol Pharmacol. 2011; 23(4):1229-34. DOI: 10.1177/039463201002300427. View

Li P, Zhu K, Mo Y, Deng X, Jiang X, Shi L . Research Progress of circRNAs in Head and Neck Cancers. Front Oncol. 2021; 11:616202. PMC: 8117014. DOI: 10.3389/fonc.2021.616202. View

Huang Y, Dai Z, Barbacioru C, Sadee W . Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005; 65(16):7446-54. DOI: 10.1158/0008-5472.CAN-04-4267. View

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

Figueroa-Gonzalez G, Carrillo-Hernandez J, Perez-Rodriguez I, Cantu de Leon D, Campos-Parra A, Martinez-Gutierrez A . Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer. Genes (Basel). 2020; 11(9). PMC: 7563199. DOI: 10.3390/genes11091058. View

Shin D, Kim E, Lee J, Roh J . Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018; 129:454-462. DOI: 10.1016/j.freeradbiomed.2018.10.426. View

10.

Koppula P, Zhang Y, Zhuang L, Gan B . Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018; 38(1):12. PMC: 5993148. DOI: 10.1186/s40880-018-0288-x. View

11.

Chen L, Yang L . Regulation of circRNA biogenesis. RNA Biol. 2015; 12(4):381-8. PMC: 4615371. DOI: 10.1080/15476286.2015.1020271. View

12.

Ye P, Mimura J, Okada T, Sato H, Liu T, Maruyama A . Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition. Mol Cell Biol. 2014; 34(18):3421-34. PMC: 4135628. DOI: 10.1128/MCB.00221-14. View

13.

Raudenska M, Balvan J, Masarik M . Cell death in head and neck cancer pathogenesis and treatment. Cell Death Dis. 2021; 12(2):192. PMC: 7893032. DOI: 10.1038/s41419-021-03474-5. View

14.

Zhu Y, He D, Bo H, Liu Z, Xiao M, Xiang L . The MRVI1-AS1/ATF3 signaling loop sensitizes nasopharyngeal cancer cells to paclitaxel by regulating the Hippo-TAZ pathway. Oncogene. 2019; 38(32):6065-6081. DOI: 10.1038/s41388-019-0858-7. View

15.

Toyokuni S . Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci. 2008; 100(1):9-16. PMC: 11158384. DOI: 10.1111/j.1349-7006.2008.01001.x. View

16.

Lajer C, Garnaes E, Friis-Hansen L, Norrild B, Therkildsen M, Glud M . The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer. Br J Cancer. 2012; 106(9):1526-34. PMC: 3341860. DOI: 10.1038/bjc.2012.109. View

17.

Roh J, Kim E, Jang H, Shin D . Aspirin plus sorafenib potentiates cisplatin cytotoxicity in resistant head and neck cancer cells through xCT inhibition. Free Radic Biol Med. 2017; 104:1-9. DOI: 10.1016/j.freeradbiomed.2017.01.002. View

18.

Zou Y, Li H, Graham E, Deik A, Eaton J, Wang W . Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020; 16(3):302-309. PMC: 7353921. DOI: 10.1038/s41589-020-0472-6. View

19.

Datta J, Smith A, Lang J, Islam M, Dutt D, Teknos T . microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ. Oncogene. 2011; 31(36):4045-53. PMC: 3307861. DOI: 10.1038/onc.2011.565. View

20.

Doll S, Proneth B, Tyurina Y, Panzilius E, Kobayashi S, Ingold I . ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2016; 13(1):91-98. PMC: 5610546. DOI: 10.1038/nchembio.2239. View