Overview and Findings from the Rush Memory and Aging Project

Overview

Journal Curr Alzheimer Res

Publisher Bentham Science Publishers

Specialty Neurology

Date 2012 Apr 5

PMID 22471867

Citations 571

Authors

David A Bennett

Julie A Schneider

Aron S Buchman

Lisa L Barnes

Patricia A Boyle

Robert S Wilson

Affiliations

Soon will be listed here.

Abstract

The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer's disease (AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: (1) the relation of motor function to cognition, disability, and death; (2) the relation of risk factors to cognitive and motor outcomes, disability and death; (3) the relation of neuropathologic indices to cognitive outcomes; (4) the relation of risk factors to neuropathologic indices; and (5) additional study findings. The findings are discussed and contextualized.

Citing Articles

The interplay between age at menopause and synaptic integrity on Alzheimer's disease risk in women.

Wood Alexander M, Honer W, Saloner R, Galea L, Bennett D, Rabin J Sci Adv. 2025; 11(10):eadt0757.

PMID: 40043118 PMC: 11881898. DOI: 10.1126/sciadv.adt0757.

Dynamic lifetime risk prediction of Alzheimer's disease with longitudinal cognitive assessment measurements.

Ding H, Ye Z, Paschalidis A, Bennett D, Au R, Lin H Alzheimers Dement. 2025; 21(3):e70055.

PMID: 40042504 PMC: 11881628. DOI: 10.1002/alz.70055.

Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits.

Vialle R, de Paiva Lopes K, Li Y, Ng B, Schneider J, Buchman A Genome Med. 2025; 17(1):20.

PMID: 40038788 PMC: 11881306. DOI: 10.1186/s13073-025-01444-6.

An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.

Biljman K, Gozes I, Lam J, Li V J Alzheimers Dis Rep. 2025; 8(1):1722-1744.

PMID: 40034341 PMC: 11863766. DOI: 10.1177/25424823241307617.

Association of late-life variability in hemoglobin A1C with postmortem neuropathologies.

Biswas R, Capuano A, Mehta R, Bennett D, Arvanitakis Z Alzheimers Dement. 2025; 21(2):e14471.

PMID: 39968681 PMC: 11863718. DOI: 10.1002/alz.14471.

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