Reconstruction of Monocyte Transcriptional Regulatory Network Accompanies Monocytic Functions in Human Fibroblasts

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Mar 20

PMID 22428058

Citations 23

Authors

Takahiro Suzuki

Mika Nakano-Ikegaya

Haruka Yabukami-Okuda

Michiel de Hoon

Jessica Severin

Satomi Saga-Hatano

Jay W Shin

Atsutaka Kubosaki

Christophe Simon

Yuki Hasegawa

Yoshihide Hayashizaki

Harukazu Suzuki

Affiliations

Soon will be listed here.

Abstract

Transcriptional regulatory networks (TRN) control the underlying mechanisms behind cellular functions and they are defined by a set of core transcription factors regulating cascades of peripheral genes. Here we report SPI1, CEBPA, MNDA and IRF8 as core transcription factors of monocyte TRN and demonstrate functional inductions of phagocytosis, inflammatory response and chemotaxis activities in human dermal fibroblasts. The Gene Ontology and KEGG pathway analyses also revealed notable representation of genes involved in immune response and endocytosis in fibroblasts. Moreover, monocyte TRN-inducers triggered multiple monocyte-specific genes based on the transcription factor motif response analysis and suggest that complex cellular TRNs are uniquely amenable to elicit cell-specific functions in unrelated cell types.

Citing Articles

MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes.

Bottardi S, Layne T, Ramon A, Quansah N, Wurtele H, Affar E Front Immunol. 2024; 15:1395035.

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Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis.

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Prediction of transcription factors associated with DNA demethylation during human cellular development.

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