Efficient Reprogramming of Adult Neural Stem Cells to Monocytes by Ectopic Expression of a Single Gene

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2010 Aug 3

PMID 20675585

Citations 20

Authors

Magda Forsberg

Marie Carlen

Konstantinos Meletis

Maggie S Y Yeung

Fanie Barnabe-Heider

Mats A A Persson

Johan Aarum

Jonas Frisen

Affiliations

Soon will be listed here.

Abstract

Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.

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