Low Serum 25-hydroxyvitamin D Level Predicts Progression to Type 2 Diabetes in Individuals with Prediabetes but Not with Normal Glucose Tolerance

Overview

Journal Diabetologia

Specialty Endocrinology

Date 2012 Mar 20

PMID 22426800

Citations 60

Authors

A Deleskog

A Hilding

K Brismar

A Hamsten

S Efendic

C-G Ostenson

Affiliations

Soon will be listed here.

Abstract

Aims/hypothesis: Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D.

Methods: At baseline, participants aged 35-56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8-10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men.

Results: Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men.

Conclusions/interpretation: High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.

Citing Articles

Glucose regulation and association with Vitamin D and parathyroid hormone - differences across Middle Eastern and Caucasian ethnicities.

Dhaher N, Wandell P, Bennet L J Diabetes Metab Disord. 2024; 24(1):15.

PMID: 39712337 PMC: 11659546. DOI: 10.1007/s40200-024-01543-y.

Association between sexual dysfunction and vitamin D in Swedish primary health care patients born in the Middle East and Sweden.

Taloyan M, Hjorleifdottir Steiner K, Ostenson C, Salminen H Sci Rep. 2024; 14(1):594.

PMID: 38182624 PMC: 10770125. DOI: 10.1038/s41598-023-50494-6.

Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome.

Lejman-Larysz K, Golara A, Baranowska M, Kozlowski M, Guzik P, Szydlowska I Nutrients. 2023; 15(13).

PMID: 37447279 PMC: 10346142. DOI: 10.3390/nu15132952.

Vitamin D in Diabetes: Uncovering the Sunshine Hormone's Role in Glucose Metabolism and Beyond.

Wu J, Atkins A, Downes M, Wei Z Nutrients. 2023; 15(8).

PMID: 37111216 PMC: 10142687. DOI: 10.3390/nu15081997.

Relationship Between Vitamin D Levels and β Cell Function and Insulin Resistance.

Ozcan C, Corapcioglu D, Cerit E Cureus. 2023; 15(1):e33970.

PMID: 36820117 PMC: 9938722. DOI: 10.7759/cureus.33970.

References

Mattila C, Knekt P, Mannisto S, Rissanen H, Laaksonen M, Montonen J . Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care. 2007; 30(10):2569-70. DOI: 10.2337/dc07-0292. View

Davidson H, Rhodes C, Hutton J . Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature. 1988; 333(6168):93-6. DOI: 10.1038/333093a0. View

Bell N, Epstein S, Greene A, Shary J, Oexmann M, Shaw S . Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. 1985; 76(1):370-3. PMC: 423785. DOI: 10.1172/JCI111971. View

Gagnon C, Lu Z, Magliano D, Dunstan D, Shaw J, Zimmet P . Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care. 2011; 34(5):1133-8. PMC: 3114481. DOI: 10.2337/dc10-2167. View

. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2003; 27 Suppl 1:S5-S10. DOI: 10.2337/diacare.27.2007.s5. View

Barengolts E . Vitamin D role and use in prediabetes. Endocr Pract. 2010; 16(3):476-85. DOI: 10.4158/EP09195.RA. View

Scragg R . Vitamin D and type 2 diabetes: are we ready for a prevention trial?. Diabetes. 2008; 57(10):2565-6. PMC: 2551662. DOI: 10.2337/db08-0879. View

Liel Y, Ulmer E, Shary J, Hollis B, Bell N . Low circulating vitamin D in obesity. Calcif Tissue Int. 1988; 43(4):199-201. DOI: 10.1007/BF02555135. View

Boucher B . Vitamin D insufficiency and diabetes risks. Curr Drug Targets. 2010; 12(1):61-87. DOI: 10.2174/138945011793591653. View

10.

Liu E, Meigs J, Pittas A, Economos C, McKeown N, Booth S . Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr. 2010; 91(6):1627-33. PMC: 2869511. DOI: 10.3945/ajcn.2009.28441. View

11.

Lewitt M, Hilding A, Ostenson C, Efendic S, Brismar K, Hall K . Insulin-like growth factor-binding protein-1 in the prediction and development of type 2 diabetes in middle-aged Swedish men. Diabetologia. 2008; 51(7):1135-45. DOI: 10.1007/s00125-008-1016-x. View

12.

Hypponen E, Boucher B, Berry D, Power C . 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes. 2007; 57(2):298-305. DOI: 10.2337/db07-1122. View

13.

Schernhammer E, Hankinson S, Hunter D, Blouin M, Pollak M . Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. Int J Cancer. 2003; 107(1):60-4. DOI: 10.1002/ijc.11358. View

14.

Grimnes G, Emaus N, Joakimsen R, Figenschau Y, Jenssen T, Njolstad I . Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med. 2010; 27(10):1107-15. DOI: 10.1111/j.1464-5491.2010.03092.x. View

15.

Baz-Hecht M, Goldfine A . The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes. 2010; 17(2):113-9. DOI: 10.1097/MED.0b013e3283372859. View

16.

Knekt P, Laaksonen M, Mattila C, Harkanen T, Marniemi J, Heliovaara M . Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008; 19(5):666-71. DOI: 10.1097/EDE.0b013e318176b8ad. View

17.

Gomez J, Maravall F, Gomez N, Navarro M, Casamitjana R, Soler J . Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Horm Metab Res. 2004; 36(1):48-53. DOI: 10.1055/s-2004-814103. View

18.

Kayaniyil S, Vieth R, Retnakaran R, Knight J, Qi Y, Gerstein H . Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care. 2010; 33(6):1379-81. PMC: 2875459. DOI: 10.2337/dc09-2321. View

19.

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

20.

Eriksson A, Ekbom A, Granath F, Hilding A, Efendic S, Ostenson C . Psychological distress and risk of pre-diabetes and Type 2 diabetes in a prospective study of Swedish middle-aged men and women. Diabet Med. 2008; 25(7):834-42. DOI: 10.1111/j.1464-5491.2008.02463.x. View