Sonic Hedgehog Signaling Pathway: A Role In Pain Processing

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2023 Feb 4

PMID 36738366

Authors

Guangda Zheng

Juanxia Ren

Lu Shang

Yanju Bao

Affiliations

Soon will be listed here.

Abstract

Pain, as one of the most prevalent clinical symptoms, is a complex physiological and psychological activity. Long-term severe pain can become unbearable to the body. However, existing treatments do not provide satisfactory results. Therefore, new mechanisms and therapeutic targets need to be urgently explored for pain management. The Sonic hedgehog (Shh) signaling pathway is crucial in embryonic development, cell differentiation and proliferation, and nervous system regulation. Here, we review the recent studies on the Shh signaling pathway and its action in multiple pain-related diseases. The Shh signaling pathway is dysregulated under various pain conditions, such as pancreatic cancer pain, bone cancer pain, chronic post-thoracotomy pain, pain caused by degenerative lumbar disc disease, and toothache. Further studies on the Shh signaling pathway may provide new therapeutic options for pain patients.

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