Interferon Gamma and Interferon Gamma Inducible Protein-10 in Detecting Tuberculosis Infection

Overview

Journal J Infect

Specialty Infectious Diseases

Date 2012 Mar 3

PMID 22381458

Citations 11

Authors

Basirudeen Syed Ahamed Kabeer

Paulkumaran Paramasivam

Alamelu Raja

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to compare the levels of TB-antigen specific Interferon gamma (IFN-γ) and IFN-γ inducible protein (IP)-10 in culture of whole blood samples from healthy controls (HC) and healthy household contacts (HHC).

Methodology: A total of 386 study subjects, which included 186 HC and 200 HHC, were recruited. QuantiFERON-TB Gold in-tube (QFT-IT) assay was employed to measure IFN-γ levels. IP-10 levels were measured in the supernatants collected from QFT-IT tubes. Tuberculin skin test was also performed.

Results: The levels of TB antigen specific IFN-γ and IP-10 were significantly higher in HHC compared to HC. There was no significant difference observed between positivity of QFT-IT and IP-10 in HC and HHC. The positivity of TST was significantly lower in subjects <17 year, when compared to IP-10 (p<0.005). The reduced cut-off point 0.22IU/ml significantly increased the positivity of QFT-IT among children with high risk for latent TB infection (LTBI).

Conclusions: Measurement of TB antigen specific IFN-γ and IP-10 can be potential markers for the detection of LTBI.

Citing Articles

Prevalence of Tuberculosis Infection among Various Risk Groups in India: A Systematic Review and Meta-Analysis.

Chauhan A, Parmar M, Dash G, Solanki H, Chauhan S, Sahoo K Indian J Community Med. 2024; 49(5):669-680.

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The prevalence of tuberculosis infection in India: A systematic review and meta-analysis.

Chauhan A, Parmar M, Dash G, Solanki H, Chauhan S, Sharma J Indian J Med Res. 2023; 157(2&3):135-151.

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Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS diodes.

De Silva T, Fawzy M, Hasani A, Ghanbari H, Abnavi A, Askar A Nat Commun. 2022; 13(1):7593.

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Electrochemical Biosensors for Cytokine Profiling: Recent Advancements and Possibilities in the Near Future.

Dutta N, Lillehoj P, Estrela P, Dutta G Biosensors (Basel). 2021; 11(3).

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Risk Factors for Indeterminate Interferon-Gamma Release Assay for the Diagnosis of Tuberculosis in Children-A Systematic Review and Meta-Analysis.

Meier N, Volken T, Geiger M, Heininger U, Tebruegge M, Ritz N Front Pediatr. 2019; 7:208.

PMID: 31192175 PMC: 6548884. DOI: 10.3389/fped.2019.00208.

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