Risk for Tuberculosis Among Children

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2006 Nov 1

PMID 17073087

Citations 42

Authors

Hiroshi Nakaoka

Lovett Lawson

S Bertel Squire

Brian Coulter

Pernille Ravn

Inger Brock

C Anthony Hart

Luis E Cuevas

Affiliations

Soon will be listed here.

Abstract

Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-y-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.

Citing Articles

Pulmonary Tuberculosis in Children: A Forgotten Disease?.

Pelosi U, Pintus R, Savasta S, Fanos V Microorganisms. 2023; 11(7).

PMID: 37512894 PMC: 10385511. DOI: 10.3390/microorganisms11071722.

Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study.

Mayito J, Martineau A, Tiwari D, Nakiyingi L, Kateete D, Reece S PLoS One. 2023; 18(3):e0281559.

PMID: 36972254 PMC: 10042355. DOI: 10.1371/journal.pone.0281559.

Review of Pediatric Tuberculosis in the Aftermath of COVID-19.

Rangchaikul P, Ahn P, Nguyen M, Zhong V, Venketaraman V Clin Pract. 2022; 12(5):738-754.

PMID: 36136871 PMC: 9498527. DOI: 10.3390/clinpract12050077.

Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?.

Maphalle L, Michniak-Kohn B, Ogunrombi M, Adeleke O Children (Basel). 2022; 9(8).

PMID: 36010011 PMC: 9406656. DOI: 10.3390/children9081120.

Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary TB patients in high TB burden countries - a systematic review and meta-analysis.

Sagili K, Muniyandi M, Shringarpure K, Singh K, Kirubakaran R, Rao R Trop Med Int Health. 2022; 27(10):842-863.

PMID: 35927930 PMC: 9825928. DOI: 10.1111/tmi.13808.

References

Huebner R, Schein M, Bass Jr J . The tuberculin skin test. Clin Infect Dis. 1993; 17(6):968-75. DOI: 10.1093/clinids/17.6.968. View

Grzybowski S, Barnett G, STYBLO K . Contacts of cases of active pulmonary tuberculosis. Bull Int Union Tuberc. 1975; 50(1):90-106. View

Vordermeier H, Chambers M, Cockle P, Whelan A, Simmons J, Hewinson R . Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis. Infect Immun. 2002; 70(6):3026-32. PMC: 128013. DOI: 10.1128/IAI.70.6.3026-3032.2002. View

Enarson P, Enarson D, Gie R . Management of tuberculosis in children in low-income countries. Int J Tuberc Lung Dis. 2006; 9(12):1299-304. View

Salaniponi F, Kwanjana J, Veen J, Misljenovic O, Borgdorff M . Risk of infection with Mycobacterium tuberculosis in Malawi: national tuberculin survey 1994. Int J Tuberc Lung Dis. 2004; 8(6):718-23. View

Brock I, Weldingh K, Lillebaek T, Follmann F, Andersen P . Comparison of tuberculin skin test and new specific blood test in tuberculosis contacts. Am J Respir Crit Care Med. 2004; 170(1):65-9. DOI: 10.1164/rccm.200402-232OC. View

Horsburgh Jr C . Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med. 2004; 350(20):2060-7. DOI: 10.1056/NEJMsa031667. View

Britton W, Gilbert G, Wheatley J, Leslie D, Rothel J, Jones S . Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis. Tuberculosis (Edinb). 2005; 85(3):137-45. DOI: 10.1016/j.tube.2004.06.003. View

Behr M, Warren S, Salamon H, Hopewell P, Ponce De Leon A, Daley C . Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli. Lancet. 1999; 353(9151):444-9. DOI: 10.1016/s0140-6736(98)03406-0. View

10.

Lockman S, Tappero J, Kenyon T, Rumisha D, Huebner R, Binkin N . Tuberculin reactivity in a pediatric population with high BCG vaccination coverage. Int J Tuberc Lung Dis. 1999; 3(1):23-30. View

11.

Shaw J, Wynn-Williams N . Infectivity of pulmonary tuberculosis in relation to sputum status. Am Rev Tuberc. 1954; 69(5):724-32. DOI: 10.1164/art.1954.69.5.724. View

12.

Pai M, Riley L, Colford Jr J . Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis. 2004; 4(12):761-76. DOI: 10.1016/S1473-3099(04)01206-X. View

13.

Howard T, Solomon D . Reading the tuberculin skin test. Who, when, and how?. Arch Intern Med. 1988; 148(11):2457-9. View

14.

Lawson L, Yassin M, Ramsay A, Emenyonu N, Squire S, Cuevas L . Comparison of scanty AFB smears against culture in an area with high HIV prevalence. Int J Tuberc Lung Dis. 2005; 9(8):933-5. View

15.

LOUDON R, Williamson J, Johnson J . An analysis of 3,485 tuberculosis contacts in the city of Edinburgh during 1954-1955. Am Rev Tuberc. 1958; 77(4):623-43. DOI: 10.1164/artpd.1958.77.4.623. View

16.

Vekemans J, Lienhardt C, Sillah J, Wheeler J, Lahai G, Doherty M . Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia. Infect Immun. 2001; 69(10):6554-7. PMC: 98797. DOI: 10.1128/IAI.69.10.6554-6557.2001. View

17.

Liebeschuetz S, Bamber S, Ewer K, Deeks J, Pathan A, Lalvani A . Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study. Lancet. 2004; 364(9452):2196-203. DOI: 10.1016/S0140-6736(04)17592-2. View

18.

Mori T, Sakatani M, Yamagishi F, Takashima T, Kawabe Y, Nagao K . Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens. Am J Respir Crit Care Med. 2004; 170(1):59-64. DOI: 10.1164/rccm.200402-179OC. View

19.

Ewer K, Deeks J, Alvarez L, Bryant G, Waller S, Andersen P . Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet. 2003; 361(9364):1168-73. DOI: 10.1016/S0140-6736(03)12950-9. View

20.

Lienhardt C, Sillah J, Fielding K, Donkor S, Manneh K, Warndorff D . Risk factors for tuberculosis infection in children in contact with infectious tuberculosis cases in the Gambia, West Africa. Pediatrics. 2003; 111(5 Pt 1):e608-14. DOI: 10.1542/peds.111.5.e608. View