Polymorphisms in 1-carbon Metabolism, Epigenetics and Folate-related Pathologies

Overview

Journal J Nutrigenet Nutrigenomics

Publisher Karger

Specialties Genetics
Nutritional Sciences

Date 2012 Feb 23

PMID 22353665

Citations 42

Authors

Patrick J Stover

Affiliations

Soon will be listed here.

Abstract

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.

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