DNA Methylation: the Nuts and Bolts of Repression

Overview

Journal J Cell Physiol

Specialties Cell Biology
Physiology

Date 2007 Aug 22

PMID 17708532

Citations 266

Authors

Tina Branscombe Miranda

Peter A Jones

Affiliations

Soon will be listed here.

Abstract

DNA methylation is an epigenetic modification which plays an important role in chromatin organization and gene expression. DNA methylation can silence genes and repetitive elements through a process which leads to the alteration of chromatin structure. The mechanisms which target DNA methylation to specific sites in the genome are not fully understood. In this review, we will discuss the mechanisms which lead to the long-term silencing of genes and will survey the progression that has been made in determining the targeted mechanisms for de novo DNA methylation.

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