Nontraditional Roles of Angiotensin-converting Enzyme

Overview

Journal Hypertension

Date 2012 Feb 23

PMID 22353608

Citations 8

Authors

Xiao Z Shen

Frank S Ong

Ellen A Bernstein

Tea Janjulia

Wendell-Lamar B Blackwell

Kandarp H Shah

Brian L Taylor

Romer A Gonzalez-Villalobos

Sebastien Fuchs

Kenneth E Bernstein

Affiliations

Soon will be listed here.

Citing Articles

Integration of Transcriptomics and Proteomics Analysis Reveals the Molecular Mechanism of Gills Exposed to Heat Stress.

Shen C, Feng G, Zhao F, Huang X, Wang M, Wang H Antioxidants (Basel). 2023; 12(12).

PMID: 38136140 PMC: 10740794. DOI: 10.3390/antiox12122020.

Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study.

Qiu G, Lin Y, Ouyang Y, You M, Zhao X, Wang H J Am Heart Assoc. 2023; 12(13):e028540.

PMID: 37382146 PMC: 10356091. DOI: 10.1161/JAHA.122.028540.

Interacting cogs in the machinery of the renin angiotensin system.

Lubbe L, Sturrock E Biophys Rev. 2019; :583-589.

PMID: 31177382 PMC: 6682192. DOI: 10.1007/s12551-019-00555-w.

Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells.

Shen X, Okwan-Duodu D, Blackwell W, Ong F, Janjulia T, Bernstein E Lab Invest. 2014; 94(5):536-44.

PMID: 24614194 PMC: 4221240. DOI: 10.1038/labinvest.2014.41.

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline.

Bernstein K, Koronyo Y, Salumbides B, Sheyn J, Pelissier L, Lopes D J Clin Invest. 2014; 124(3):1000-12.

PMID: 24487585 PMC: 3934162. DOI: 10.1172/JCI66541.

References

MacMicking J, Xie Q, Nathan C . Nitric oxide and macrophage function. Annu Rev Immunol. 1997; 15:323-50. DOI: 10.1146/annurev.immunol.15.1.323. View

Sosne G, Qiu P, Goldstein A, Wheater M . Biological activities of thymosin beta4 defined by active sites in short peptide sequences. FASEB J. 2010; 24(7):2144-51. DOI: 10.1096/fj.09-142307. View

Fuchs S, Xiao H, Hubert C, Michaud A, Campbell D, Adams J . Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension. 2007; 51(2):267-74. DOI: 10.1161/HYPERTENSIONAHA.107.097865. View

Ferrario C . ACE2: more of Ang-(1-7) or less Ang II?. Curr Opin Nephrol Hypertens. 2010; 20(1):1-6. PMC: 5826562. DOI: 10.1097/MNH.0b013e3283406f57. View

Shiloh M, MacMicking J, Nicholson S, Brause J, Potter S, Marino M . Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 1999; 10(1):29-38. DOI: 10.1016/s1074-7613(00)80004-7. View

Matsusaka T, Miyazaki Y, Ichikawa I . The renin angiotensin system and kidney development. Annu Rev Physiol. 2002; 64:551-61. DOI: 10.1146/annurev.physiol.64.081501.155721. View

Cornell M, Williams T, Lamango N, Coates D, Corvol P, Soubrier F . Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. J Biol Chem. 1995; 270(23):13613-9. DOI: 10.1074/jbc.270.23.13613. View

Cole J, Ertoy D, Lin H, Sutliff R, Ezan E, Guyene T . Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J Clin Invest. 2000; 106(11):1391-8. PMC: 381466. DOI: 10.1172/JCI10557. View

Rousseau A, Michaud A, Chauvet M, Lenfant M, Corvol P . The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem. 1995; 270(8):3656-61. DOI: 10.1074/jbc.270.8.3656. View

10.

Jaspard E, Wei L, Alhenc-Gelas F . Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides. J Biol Chem. 1993; 268(13):9496-503. View

11.

Platten M, Youssef S, Hur E, Ho P, Han M, Lanz T . Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A. 2009; 106(35):14948-53. PMC: 2736463. DOI: 10.1073/pnas.0903958106. View

12.

Xiao H, Fuchs S, Frenzel K, Teng L, Li P, Shen X . The use of knockout mouse technology to achieve tissue selective expression of angiotensin converting enzyme. J Mol Cell Cardiol. 2004; 36(6):781-9. DOI: 10.1016/j.yjmcc.2004.02.013. View

13.

Wei L, Clauser E, Alhenc-Gelas F, Corvol P . The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J Biol Chem. 1992; 267(19):13398-405. View

14.

Esther Jr C, Howard T, Marino E, Goddard J, Capecchi M, Bernstein K . Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest. 1996; 74(5):953-65. View

15.

Azizi M, Rousseau A, Ezan E, Guyene T, Michelet S, Grognet J . Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline. J Clin Invest. 1996; 97(3):839-44. PMC: 507123. DOI: 10.1172/JCI118484. View

16.

Shen X, Billet S, Lin C, Okwan-Duodu D, Chen X, Lukacher A . The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat Immunol. 2011; 12(11):1078-85. PMC: 3197883. DOI: 10.1038/ni.2107. View

17.

Himes S, Tagoh H, Goonetilleke N, Sasmono T, Oceandy D, Clark R . A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol. 2001; 70(5):812-20. View

18.

Shen X, Bernstein K . The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis. Cell Cycle. 2011; 10(9):1363-9. PMC: 3117040. DOI: 10.4161/cc.10.9.15444. View

19.

Sasmono R, Oceandy D, Pollard J, Tong W, Pavli P, Wainwright B . A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood. 2002; 101(3):1155-63. DOI: 10.1182/blood-2002-02-0569. View

20.

Okwan-Duodu D, Datta V, Shen X, Goodridge H, Bernstein E, Fuchs S . Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010; 285(50):39051-60. PMC: 2998083. DOI: 10.1074/jbc.M110.163782. View