Pannexin 1 Forms an Anion-selective Channel

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2012 Feb 8

PMID 22311122

Citations 70

Authors

Weihong Ma

Vincent Compan

Wenxuan Zheng

Elizabeth Martin

R Alan North

Alexei Verkhratsky

Annmarie Surprenant

Affiliations

Soon will be listed here.

Abstract

Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.

Citing Articles

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