Targeting Pannexin-1 Channels: Addressing the 'Gap' in Chronic Pain

Overview

Journal CNS Drugs

Specialties Neurology
Pharmacology

Date 2024 Feb 14

PMID 38353876

Authors

Brendan B McAllister

Sierra Stokes-Heck

Erika K Harding

Nynke J van den Hoogen

Tuan Trang

Affiliations

Soon will be listed here.

Abstract

Chronic pain complicates many diseases and is notoriously difficult to treat. In search of new therapeutic targets, pannexin-1 (Panx1) channels have sparked intense interest as a key mechanism involved in a variety of chronic pain conditions. Panx1 channels are transmembrane proteins that release ions and small molecules, such as adenosine triphosphate (ATP). They are expressed along important nodes of the pain pathway, modulating activity of diverse cell types implicated in the development and progression of chronic pain caused by injury or pathology. This review highlights advances that have unlocked the core structure and machinery controlling Panx1 function with a focus on understanding and treating chronic pain.

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