Cellular Dysfunction in Diabetes As Maladaptive Response to Mitochondrial Oxidative Stress

Overview

Journal Exp Diabetes Res

Specialty Endocrinology

Date 2012 Jan 19

PMID 22253615

Citations 48

Authors

Alba Naudi

Mariona Jove

Victoria Ayala

Anna Cassanye

Jose Serrano

Hugo Gonzalo

Jordi Boada

Joan Prat

Manuel Portero-Otin

Reinald Pamplona

Affiliations

Soon will be listed here.

Abstract

Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage.

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