Interferon Regulatory Factor 1 (IRF-1) Induces P21(WAF1/CIP1) Dependent Cell Cycle Arrest and P21(WAF1/CIP1) Independent Modulation of Survivin in Cancer Cells

Overview

Journal Cancer Lett

Specialty Oncology

Date 2011 Dec 28

PMID 22200613

Citations 22

Authors

Michaele J Armstrong

Michael T Stang

Ye Liu

Jinbo Gao

Baoguo Ren

Brian S Zuckerbraun

Raja S Mahidhara

Quanhua Xing

Eva Pizzoferrato

John H Yim

Affiliations

Soon will be listed here.

Abstract

We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.

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