From G0 to S Phase: a View of the Roles Played by the Retinoblastoma (Rb) Family Members in the Rb-E2F Pathway

Overview

Journal J Cell Biochem

Specialties Biochemistry
Cell Biology

Date 2007 Nov 6

PMID 17979151

Citations 70

Authors

Ang Sun

Luigi Bagella

Steven Tutton

Gaetano Romano

Antonio Giordano

Affiliations

Soon will be listed here.

Abstract

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.

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