CNTF and Retina

Overview

Journal Prog Retin Eye Res

Specialty Ophthalmology

Date 2011 Dec 21

PMID 22182585

Citations 99

Authors

Rong Wen

Weng Tao

Yiwen Li

Paul A Sieving

Affiliations

Soon will be listed here.

Abstract

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases.

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