The Role of Interleukin-6 Family Members in Cardiovascular Diseases

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Apr 11

PMID 35402550

Authors

Yongqi Feng

Di Ye

Zhen Wang

Heng Pan

Xiyi Lu

Menglong Wang

Yao Xu

Junping Yu

Jishou Zhang

Mengmeng Zhao

Shuwan Xu

Wei Pan

Zheng Yin

Jing Ye

Jun Wan

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a series of cytokines, including IL-6, IL-11, IL-30, IL-31, OSM, LIF, CNTF, CT-1, CT-2, and CLC, that regulate multiple biological effects. Experimental and clinical evidence shows that IL-6 family members are closely related to cardiovascular diseases such as atherosclerosis, hypertension, aortic dissection, cardiac fibrosis, and cardiomyopathy. This review mainly discusses the role of IL-6 family members in cardiovascular disease for the sake of identifying possible intervention targets for cardiovascular disease prevention and treatment.

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