Defective Retrovirus-like 30S RNA Species of Rat and Mouse Cells Are Infectious if Packaged by Type C Helper Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1979 Mar 1

PMID 221684

Citations 42

Authors

E M Scolnick

W C Vass

R S Howk

P H Duesberg

Affiliations

Soon will be listed here.

Abstract

RNA species with properties of defective retrovirus-like 30S RNA genomes have previously been detected in both rats and mice and in some rat and mouse retroviruses. Using cell lines which express high levels of this retrovirus-like RNA, we formed pseudotypes of the 30S RNAs with helper-independent type C viruses. A pseudotype virus complex containing a mouse 30S subunit was transmitted to rat cells, and a pseudotype virus complex containing a rat 30S subunit was transmitted to bat cells. In other transmission experiments, a rat 30S subunit was isolated in nonproducer bat cells without detectable expression of the helper-independent type C virus used to pseudotype it. The results provide further support for the retrovirus-like nature of the rat 30S subunit and provide evidence which supports the protovirus hypothesis proposed by Temin.

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