Identification of a 30S RNA with Properties of a Defective Type C Virus in Murine Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1978 Jan 1

PMID 202730

Citations 44

Authors

R S Howk

D H Troxler

D Lowy

P H Duesberg

E M Scolnick

Affiliations

Soon will be listed here.

Abstract

A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The properties of the 30S RNA suggest that it is a defective endogenous mouse type C virus and that it is analogous to a previously described class of defective endogenous rat type C virus, which has been shown previously to be the progenitor of Kirsten and Harvey murine sarcoma viruses.

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