Jeroen P J Saeij
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Explore the profile of Jeroen P J Saeij including associated specialties, affiliations and a list of published articles.
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79
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3221
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Recent Articles
1.
Ten Hoeve A, Rodriguez M, Saflund M, Michel V, Magimel L, Ripoll A, et al.
mBio
. 2024 Aug;
15(10):e0214024.
PMID: 39207098
Importance: Intracellular pathogens can hijack the cellular functions of infected host cells to their advantage, for example, for intracellular survival and dissemination. However, how microbes orchestrate the hijacking of complex...
2.
Morales P, Brown A, Sangare L, Yang S, Kuihon S, Chen B, et al.
Cell Mol Life Sci
. 2024 Jul;
81(1):294.
PMID: 38977495
The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma relies on its swift dissemination to the central nervous system through a 'Trojan Horse'...
3.
Gupta P, Hiller A, Chowdhury J, Lim D, Lim D, Saeij J, et al.
Virus Evol
. 2024 May;
10(1):veae040.
PMID: 38817668
We are entering a 'Platinum Age of Virus Discovery', an era marked by exponential growth in the discovery of virus biodiversity, and driven by advances in metagenomics and computational analysis....
4.
Bitew M, Gaete P, Swale C, Maru P, Contreras J, Saeij J
mBio
. 2024 Feb;
15(3):e0308123.
PMID: 38380952
Importance: is a parasite that poses significant health risks to those with impaired immunity. It replicates inside host cells shielded by the PVM, which controls nutrient and waste exchange with...
5.
Wang Y, Hollingsworth L, Sangare L, Paredes-Santos T, Krishnamurthy S, Penn B, et al.
mBio
. 2024 Feb;
15(3):e0330223.
PMID: 38376248
is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood. In this study, we performed...
6.
Ten Hoeve A, Rodriguez M, Saflund M, Michel V, Magimel L, Ripoll A, et al.
bioRxiv
. 2024 Feb;
PMID: 38370679
Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite Here, we report how a set of secreted parasite effector proteins from dense granule organelles (GRA) orchestrates dendritic cell-like chemotactic...
7.
Wang Y, Hollingsworth L, Sangare L, Paredes-Santos T, Krishnamurthy S, Penn B, et al.
bioRxiv
. 2024 Jan;
PMID: 38168400
is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood. In this study, we performed...
8.
Bitew M, Gaete P, Swale C, Maru P, Contreras J, Saeij J
bioRxiv
. 2023 Nov;
PMID: 38014337
, a medically important intracellular parasite, uses GRA proteins, secreted from dense granule organelles, to mediate nutrient flux across the parasitophorous vacuole membrane (PVM). GRA17 and GRA23 are known pore-forming...
9.
Paredes-Santos T, Bitew M, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, et al.
PLoS Pathog
. 2023 Jul;
19(7):e1011543.
PMID: 37498952
Toxoplasma gondii is a parasite that replicates within a specialized compartment called the parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain essential nutrients, Toxoplasma must...
10.
Krishnamurthy S, Maru P, Wang Y, Bitew M, Mukhopadhyay D, Yamaryo-Botte Y, et al.
mBio
. 2023 Mar;
14(2):e0006023.
PMID: 36916910
virulence depends on its ability to evade or survive the toxoplasmacidal mechanisms induced by interferon gamma (IFNγ). While many genes involved in the evasion of the murine IFNγ response have...