On Improving the Speed and Reliability of T2-relaxation-under-spin-tagging (TRUST) MRI

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2011 Dec 1

PMID 22127845

Citations 48

Authors

Feng Xu

Jinsoo Uh

Peiying Liu

Hanzhang Lu

Affiliations

Soon will be listed here.

Abstract

A T(2) -relaxation-under-spin-tagging technique was recently developed to estimate cerebral blood oxygenation, providing potentials for noninvasive assessment of the brain's oxygen consumption. A limitation of the current sequence is the need for long repetition time, as shorter repetition time causes an over-estimation in blood R(2). This study proposes a postsaturation T(2)-relaxation-under-spin-tagging by placing a nonselective 90° pulse after the signal acquisition to reset magnetization in the whole brain. This scheme was found to eliminate estimation bias at a slight cost of precision. To improve the precision, echo time of the sequence was optimized and it was found that a modest echo time shortening of 3.4 ms can reduce the estimation error by 49%. We recommend the use of postsaturation T(2)-relaxation-under-spin-tagging sequence with a repetition time of 3000 ms and a echo time of 3.6 ms, which allows the determination of global venous oxygenation with scan duration of 1 min 12 s and an estimation precision of ± 1% (in units of oxygen saturation percentage).

Citing Articles

Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.

Wehrli F Magn Reson Med Sci. 2024; 23(3):377-403.

PMID: 38866481 PMC: 11234951. DOI: 10.2463/mrms.rev.2024-0028.

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls.

Fellah S, Ying C, Wang Y, Guilliams K, Fields M, Chen Y J Cereb Blood Flow Metab. 2024; 44(8):1404-1416.

PMID: 38436254 PMC: 11342725. DOI: 10.1177/0271678X241237072.

VICTR: Venous transit time imaging by changes in T relaxation.

Shi W, Jiang D, Hu Z, Yedavalli V, Ge Y, Moghekar A Magn Reson Med. 2024; 92(1):158-172.

PMID: 38411277 PMC: 11055660. DOI: 10.1002/mrm.30051.

Toward vendor-independent measurement of cerebral venous oxygenation: Comparison of TRUST MRI across three major MRI manufacturers and association with end-tidal CO.

Eldirdiri A, Zhuo J, Lin Z, Lu H, Gullapalli R, Jiang D NMR Biomed. 2023; 36(10):e4990.

PMID: 37315951 PMC: 10801912. DOI: 10.1002/nbm.4990.

Review of the Research Progress of Human Brain Oxygen Extraction Fraction by Magnetic Resonance Imaging.

Jian Z, Wang X, Tian M, Liu Y, Yao H, Gong L Oxid Med Cell Longev. 2022; 2022:4554271.

PMID: 36304964 PMC: 9596244. DOI: 10.1155/2022/4554271.

References

Fernandez-Seara M, Techawiboonwong A, Detre J, Wehrli F . MR susceptometry for measuring global brain oxygen extraction. Magn Reson Med. 2006; 55(5):967-73. DOI: 10.1002/mrm.20892. View

Xu F, Uh J, Brier M, Hart Jr J, Yezhuvath U, Gu H . The influence of carbon dioxide on brain activity and metabolism in conscious humans. J Cereb Blood Flow Metab. 2010; 31(1):58-67. PMC: 3049465. DOI: 10.1038/jcbfm.2010.153. View

Lu H, Zhao C, Ge Y, Lewis-Amezcua K . Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signals. Magn Reson Med. 2008; 60(2):364-72. PMC: 2597505. DOI: 10.1002/mrm.21686. View

van Osch M, Teeuwisse W, van Walderveen M, Hendrikse J, Kies D, van Buchem M . Can arterial spin labeling detect white matter perfusion signal?. Magn Reson Med. 2009; 62(1):165-73. DOI: 10.1002/mrm.22002. View

Bolar D, Rosen B, Sorensen A, Adalsteinsson E . QUantitative Imaging of eXtraction of oxygen and TIssue consumption (QUIXOTIC) using venular-targeted velocity-selective spin labeling. Magn Reson Med. 2011; 66(6):1550-62. PMC: 3217089. DOI: 10.1002/mrm.22946. View

Xu F, Ge Y, Lu H . Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med. 2009; 62(1):141-8. PMC: 2726987. DOI: 10.1002/mrm.21994. View

Sutton B, Ouyang C, Ching B, Ciobanu L . Functional imaging with FENSI: flow-enhanced signal intensity. Magn Reson Med. 2007; 58(2):396-401. DOI: 10.1002/mrm.21325. View

Silvennoinen M, Clingman C, Golay X, Kauppinen R, van Zijl P . Comparison of the dependence of blood R2 and R2* on oxygen saturation at 1.5 and 4.7 Tesla. Magn Reson Med. 2003; 49(1):47-60. DOI: 10.1002/mrm.10355. View

Lu H, Xu F, Grgac K, Liu P, Qin Q, van Zijl P . Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med. 2011; 67(1):42-9. PMC: 3158970. DOI: 10.1002/mrm.22970. View

10.

KETY S, Schmidt C . THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN. J Clin Invest. 1948; 27(4):484-92. PMC: 439519. DOI: 10.1172/JCI101995. View

11.

van Zijl P, Eleff S, Ulatowski J, Oja J, Ulug A, Traystman R . Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med. 1998; 4(2):159-67. DOI: 10.1038/nm0298-159. View

12.

Lu H, Clingman C, Golay X, van Zijl P . Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med. 2004; 52(3):679-82. DOI: 10.1002/mrm.20178. View

13.

Lu H, Xu F, Rodrigue K, Kennedy K, Cheng Y, Flicker B . Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex. 2010; 21(6):1426-34. PMC: 3097991. DOI: 10.1093/cercor/bhq224. View

14.

Davis T, Kwong K, Weisskoff R, Rosen B . Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A. 1998; 95(4):1834-9. PMC: 19199. DOI: 10.1073/pnas.95.4.1834. View

15.

Hoge R, Atkinson J, Gill B, Crelier G, Marrett S, Pike G . Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A. 1999; 96(16):9403-8. PMC: 17795. DOI: 10.1073/pnas.96.16.9403. View

16.

Durduran T, Zhou C, Buckley E, Kim M, Yu G, Choe R . Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects. J Biomed Opt. 2010; 15(3):037004. PMC: 2887915. DOI: 10.1117/1.3425884. View

17.

An H, Lin W . Impact of intravascular signal on quantitative measures of cerebral oxygen extraction and blood volume under normo- and hypercapnic conditions using an asymmetric spin echo approach. Magn Reson Med. 2003; 50(4):708-16. DOI: 10.1002/mrm.10576. View

18.

Tsuchida C, Kimura H, Sadato N, Tsuchida T, Tokuriki Y, Yonekura Y . Evaluation of brain metabolism in steno-occlusive carotid artery disease by proton MR spectroscopy: a correlative study with oxygen metabolism by PET. J Nucl Med. 2000; 41(8):1357-62. View

19.

Hendrikse J, Lu H, van der Grond J, van Zijl P, Golay X . Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT. Magn Reson Med. 2003; 50(2):429-33. DOI: 10.1002/mrm.10525. View

20.

Haacke E, Lai S, Reichenbach J, Kuppusamy K, Hoogenraad F, Takeichi H . In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging. Hum Brain Mapp. 2010; 5(5):341-6. DOI: 10.1002/(SICI)1097-0193(1997)5:5<341::AID-HBM2>3.0.CO;2-3. View