Review of the Research Progress of Human Brain Oxygen Extraction Fraction by Magnetic Resonance Imaging

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2022 Oct 28

PMID 36304964

Authors

Zini Jian

Xianpei Wang

Meng Tian

Yufei Liu

Hongtai Yao

Li Gong

Bowen Li

Affiliations

Soon will be listed here.

Abstract

In recent years, the incidence of cerebrovascular diseases (CVD) is increasing, which seriously endangers human health. The study on hemodynamics of cerebrovascular disease can help us to understand, prevent, and treat the disease. As one of the important parameters of human cerebral hemodynamics and tissue metabolism, OEF (oxygen extraction fraction) is of great value in central nervous system diseases. The use of BOLD (blood oxygen level dependent) effect offers the possibility to study cerebral hemodynamic and metabolic characteristics by MRI (magnetic resonance imaging) measurements. Therefore, this paper reviews the hemodynamic parameters of brain tissue, discusses the principles and methods of quantitative BOLD-based MRI measurements of OEF, and discusses the advantages and disadvantages of each method.

Citing Articles

Research Progress on Glioma Microenvironment and Invasiveness Utilizing Advanced Multi-Parametric Quantitative MRI.

Song D, Fan G, Chang M Cancers (Basel). 2025; 17(1.

PMID: 39796702 PMC: 11719598. DOI: 10.3390/cancers17010074.

References

Cho J, Lee J, An H, Goyal M, Su Y, Wang Y . Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with O PET in healthy adults. J Cereb Blood Flow Metab. 2020; 41(7):1658-1668. PMC: 8221765. DOI: 10.1177/0271678X20973951. View

Derdeyn C, Videen T, Yundt K, Fritsch S, Carpenter D, Grubb R . Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited. Brain. 2002; 125(Pt 3):595-607. DOI: 10.1093/brain/awf047. View

He X, Zhu M, Yablonskiy D . Validation of oxygen extraction fraction measurement by qBOLD technique. Magn Reson Med. 2008; 60(4):882-8. PMC: 2812065. DOI: 10.1002/mrm.21719. View

Ibaraki M, Miura S, Shimosegawa E, Sugawara S, Mizuta T, Ishikawa A . Quantification of cerebral blood flow and oxygen metabolism with 3-dimensional PET and 15O: validation by comparison with 2-dimensional PET. J Nucl Med. 2007; 49(1):50-9. DOI: 10.2967/jnumed.107.044008. View

Wintermark M, Sesay M, Barbier E, Borbely K, Dillon W, Eastwood J . Comparative overview of brain perfusion imaging techniques. Stroke. 2005; 36(9):e83-99. DOI: 10.1161/01.STR.0000177884.72657.8b. View

Lu H, Ge Y . Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magn Reson Med. 2008; 60(2):357-63. PMC: 2587050. DOI: 10.1002/mrm.21627. View

Hattori N, Bergsneider M, Wu H, Glenn T, Vespa P, Hovda D . Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans. J Nucl Med. 2004; 45(5):765-70. View

Cho J, Zhang S, Kee Y, Spincemaille P, Nguyen T, Hubertus S . Cluster analysis of time evolution (CAT) for quantitative susceptibility mapping (QSM) and quantitative blood oxygen level-dependent magnitude (qBOLD)-based oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO ) mapping. Magn Reson Med. 2019; 83(3):844-857. PMC: 6879790. DOI: 10.1002/mrm.27967. View

Ogawa S, Lee T, Kay A, Tank D . Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A. 1990; 87(24):9868-72. PMC: 55275. DOI: 10.1073/pnas.87.24.9868. View

10.

Ishii K, Kitagaki H, Kono M, Mori E . Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by PET. J Nucl Med. 1996; 37(7):1159-65. View

11.

Tanaka M, Kondo S, Okamoto K, Hirai S . [Cerebral perfusion and oxygen metabolism in Parkinson's disease: positron emission tomographic study using oxygen-15-labeled CO2 and O2]. Nihon Rinsho. 1997; 55(1):218-21. View

12.

Ogawa S, Menon R, Tank D, Kim S, Merkle H, Ellermann J . Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J. 1993; 64(3):803-12. PMC: 1262394. DOI: 10.1016/S0006-3495(93)81441-3. View

13.

Xie S . MR OEF imaging in MELAS. Methods Enzymol. 2014; 547:433-44. DOI: 10.1016/B978-0-12-801415-8.00021-7. View

14.

Lee J, Vo K, An H, Celik A, Lee Y, Hsu C . Magnetic resonance cerebral metabolic rate of oxygen utilization in hyperacute stroke patients. Ann Neurol. 2003; 53(2):227-32. DOI: 10.1002/ana.10433. View

15.

Powers W, Videen T, Markham J, McGee-Minnich L, Antenor-Dorsey J, Hershey T . Selective defect of in vivo glycolysis in early Huntington's disease striatum. Proc Natl Acad Sci U S A. 2007; 104(8):2945-9. PMC: 1797149. DOI: 10.1073/pnas.0609833104. View

16.

Yablonskiy D, Haacke E . An MRI method for measuring T2 in the presence of static and RF magnetic field inhomogeneities. Magn Reson Med. 1997; 37(6):872-6. DOI: 10.1002/mrm.1910370611. View

17.

An H, Ford A, Vo K, Liu Q, Chen Y, Lee J . Imaging Oxygen Metabolism In Acute Stroke Using MRI. Curr Radiol Rep. 2014; 2(3):39. PMC: 3972627. DOI: 10.1007/s40134-013-0039-3. View

18.

An H, Lin W . Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging. J Cereb Blood Flow Metab. 2000; 20(8):1225-36. PMC: 4096835. DOI: 10.1097/00004647-200008000-00008. View

19.

Attwell D, Laughlin S . An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001; 21(10):1133-45. DOI: 10.1097/00004647-200110000-00001. View

20.

An H, Lin W . Impact of intravascular signal on quantitative measures of cerebral oxygen extraction and blood volume under normo- and hypercapnic conditions using an asymmetric spin echo approach. Magn Reson Med. 2003; 50(4):708-16. DOI: 10.1002/mrm.10576. View