Association Between PARP-1 V762A Polymorphism and Cancer Susceptibility: a Meta-analysis

Overview

Journal Genet Epidemiol

Specialties Genetics
Public Health

Date 2011 Dec 1

PMID 22127734

Citations 20

Authors

Hongping Yu

Hongxia Ma

Ming Yin

Qingyi Wei

Affiliations

Soon will be listed here.

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death. PARP-1 has been implicated in human carcinogenesis, but the association between the most-studied PARP-1 V762A polymorphism (rs1136410) and risk of various cancers was reported with inconclusive results. The aim of this study was to assess the association between the PARP-1 V762A polymorphism and cancer risk. A meta-analysis of 21 studies with 12,027 cancer patients and 14,106 cancer-free controls was conducted to evaluate the strength of the association using odds ratio (OR) with 95% confidence interval (CI). Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer risk. In the stratified analyses, however, it was found that the variant A allele of the PARP-1 V762A polymorphism was associated with an increased risk of cancer among Asian populations (VA + AA vs. VV: OR = 1.11, 95% CI: 1.01-1.23; P(heterogeneity) = 0.210), but a decreased risk of cancer (VA + AA vs. VV: OR = 0.89, 95% CI: 0.80-1.00; P(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (OR = 0.79, 95% CI: 0.69-0.90; P(heterogeneity) = 0.800). This meta-analysis found evidence for an association of the PARP-1 V 762A polymorphism with increased risk of cancer among Asians, but decreased risk of cancer among Caucasians, particularly of glioma. Further well-designed studies with large sample sizes of different ethnic populations and different cancer types are warranted to confirm these findings.

Citing Articles

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition.

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A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.

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High Poly(ADP-Ribose) Polymerase Expression Does Relate to Poor Survival in Solid Cancers: A Systematic Review and Meta-Analysis.

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rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis.

Xin Y, Yang L, Su M, Cheng X, Zhu L, Liu J J Int Med Res. 2021; 49(3):300060521992956.

PMID: 33706586 PMC: 8168028. DOI: 10.1177/0300060521992956.

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