From Fly Wings to Targeted Cancer Therapies: a Centennial for Notch Signaling

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2014 Mar 22

PMID 24651013

Citations 207

Authors

Panagiotis Ntziachristos

Jing Shan Lim

Julien Sage

Iannis Aifantis

Affiliations

Soon will be listed here.

Abstract

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.

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