Characterization of Natural Killer Cell Phenotype and Function During Recurrent Human HSV-2 Infection

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Nov 24

PMID 22110712

Citations 34

Authors

Niklas K Bjorkstrom

Alexandra Svensson

Karl-Johan Malmberg

Kristina Eriksson

Hans-Gustaf Ljunggren

Affiliations

Soon will be listed here.

Abstract

Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, and HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, and HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.

Citing Articles

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications.

Siemaszko J, Marzec-Przyszlak A, Bogunia-Kubik K Arch Immunol Ther Exp (Warsz). 2023; 71(1):9.

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HLA-B*57:01 Complexed to a CD8 T-Cell Epitope from the HSV-2 ICP22 Protein Binds NK and T Cells through KIR3DL1.

Laing K, Campbell V, Dong L, Koelle D Viruses. 2022; 14(5).

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Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.

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PMID: 35181606 PMC: 8872722. DOI: 10.1073/pnas.2116588119.

The Contribution of Human Herpes Viruses to γδ T Cell Mobilisation in Co-Infections.

Martini F, Champagne E Viruses. 2021; 13(12).

PMID: 34960641 PMC: 8704314. DOI: 10.3390/v13122372.

Natural killer cells in antiviral immunity.

Bjorkstrom N, Strunz B, Ljunggren H Nat Rev Immunol. 2021; 22(2):112-123.

PMID: 34117484 PMC: 8194386. DOI: 10.1038/s41577-021-00558-3.

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