Methylenebissantin: a Rare Methylene-bridged Bisflavonoid from Dodonaea Viscosa Which Inhibits Plasmodium Falciparum Enoyl-ACP Reductase

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2011 Nov 16

PMID 22082562

Citations 7

Authors

Akhtar Muhammad

Itrat Anis

Zulfiqar Ali

Sufyan Awadelkarim

Ajmal Khan

Asaad Khalid

Muhammad Raza Shah

M Galal

Ikhlas A Khan

M Iqbal Choudhary

Affiliations

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Abstract

A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC(50) 91.13 μM) against PfENR.

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