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Polyhydroxylated Steroids from the Bamboo Coral Isis Hippuris

Overview
Journal Mar Drugs
Publisher MDPI
Specialties Biology
Pharmacology
Date 2011 Nov 11
PMID 22072998
Citations 12
Authors
Wei-Hua Chen
Shang-Kwei Wang
Chang-Yih Duh
Affiliations
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Abstract

In previous studies on the secondary metabolites of the Taiwanese octocoral Isis hippuris, specimens have always been collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Taiwanese octocoral I. hippuris collected at Orchid Island have led to the isolation of five new polyoxygenated steroids: hipposterone M-O (1-3), hipposterol G (4) and hippuristeroketal A (5). The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cell lines were evaluated. Compound 2 exhibited inhibitory activity against HCMV, with an EC(50) value of 6.0 μg/mL.

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